Advanced Biomaterials for Primary Prevention in Dentistry

A Special Issue of Journal of Functional Biomaterials (ISSN 2079-4983) belonging to the section "Dental Biomaterials".

Deadline for manuscript submissions: 31 March 2027 | Viewed by 884

Editors

Department of Community Dentistry, School of Dental Medicine, Hebrew University and Hadassah, Jerusalem 91120, Israel
Interests: public health dentistry; primary prophylaxis; artificial intelligence (AI) in medicine; bioactive biomaterials; translational research; tissue preservation; epidemiological mitigation

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Guest Editor
Department of Community Dentistry, School of Dental Medicine, Hebrew University and Hadassah, Jerusalem 91120, Israel
Interests: public health dentistry; primary prevention; health promotion; community care epidemiology; underserved populations; bioactive biomaterials

Special Issue Information

Dear Colleagues,

The objective of this Special Issue is to consolidate groundbreaking research that moves dental medicine from a reactive (restorative) model to a proactive (preventative) paradigm. While traditional dentistry focuses on repairing damage caused by caries and periodontal disease, this issue focuses on the science of the interface—materials designed to intervene before irreversible tissue loss occurs.

The scope includes, but is not limited to:

  • Bio-instructive Scaffolds: Materials that guide tissue remineralization and bolster the tooth's natural structural integrity.
  • Smart Antimicrobial Surfaces: Development of "responsive" coatings that release therapeutic agents only in the presence of pathogenic pH shifts or enzymatic triggers.
  • Nanofluorapatite and Bioactive Glass: Innovations in synthetic minerals that mimic natural enamel and dentin to arrest early-stage demineralization.
  • Preventative Periodontology: Advanced membranes and local delivery systems designed to inhibit biofilm formation and maintain the integrity of the periodontium.
  • Salivary Diagnostics and Biosensors: Integration of biomaterials into wearable or intra-oral devices for the real-time monitoring of biomarkers associated with oral systemic health.

Purpose: To bridge the gap between materials science and clinical prophylaxis, providing a roadmap for the next generation of non-invasive dental interventions that reduce the global burden of oral disease.

Dr. Guy Tobias
Prof. Yuval Vered
Guest Editors

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Keywords

  • bioactive biomaterials
  • primary prevention
  • tooth remineralization
  • biofilm management
  • smart materials
  • translational dentistry
  • tissue preservation

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Published Papers (1 paper)

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39 pages, 2082 KB  
Systematic Review
Methodological Heterogeneity in Profilometric Assessment of Experimentally Demineralized Enamel as a Model of White Spot Lesions: A Systematic Review
by Nadina Ilincar, Vanessa Bolchis, Mariana-Ioana Miron, Alexandru-Ionut Olari, Ramona Dumitrescu, Razvan Lacatusu, Daniela Jumanca and Atena Galuscan
J. Funct. Biomater. 2026, 17(9), 429; https://doi.org/10.3390/jfb17090429 - 25 Aug 2026
Viewed by 526
Abstract
Introduction: White spot lesions (WSLs) are early enamel demineralization lesions associated with increased surface roughness and plaque retention. Profilometry is commonly used to evaluate these surface changes, although methodological variability remains significant. Objective: To critically evaluate the available evidence regarding the validity and [...] Read more.
Introduction: White spot lesions (WSLs) are early enamel demineralization lesions associated with increased surface roughness and plaque retention. Profilometry is commonly used to evaluate these surface changes, although methodological variability remains significant. Objective: To critically evaluate the available evidence regarding the validity and reproducibility of profilometry for assessing surface roughness in experimentally induced WSL models and treatment-modified surfaces and to identify methodological factors influencing its application across in vitro studies. Methods: A systematic review of 27 in vitro studies published between 2021 and 2026 was conducted. Methodological characteristics of contact and non-contact profilometry were synthesized, and evidence relevant to validity and reproducibility was qualitatively assessed based on complementary analytical methods and the reporting of standardized measurement procedures. Results: Considerable heterogeneity was identified in specimen sample and preparation, demineralization protocols, profilometric systems, acquisition settings, roughness parameters, and experimental conditions. Both contact and non-contact profilometry detected treatment- and demineralization-related surface changes, with Ra being the most frequent reported parameter. Complementary analytical techniques provided supporting evidence for the interpretation of profilometric findings but did not constitute formal validation. Methodological details relevant to reproducibility were inconsistently reported, and formal repeatability or reproducibility testing was generally lacking, Conclusion: Profilometry appears useful for quantitatively characterizing surface topography in experimentally demineralized enamel as a model of WSLs and treatment-modified enamel; however, substantial methodological variability and limited formal validation and reproducibility testing prevent definitive conclusions regarding its validity and reproducibility. Greater standardization of methodologies of measurement and reporting protocols is required to improve comparability and strengthen the evidence base. Full article
(This article belongs to the Special Issue Advanced Biomaterials for Primary Prevention in Dentistry)
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