Special Issue "Matrix Remodelling during Development"

A special issue of Journal of Developmental Biology (ISSN 2221-3759).

Deadline for manuscript submissions: 30 September 2019.

Special Issue Editor

Guest Editor
Prof. Dr. Bryan D. Crawford Website E-Mail
Department of Biology, University of New Brunswick, NB, Canada
Interests: cell–matrix interactions; extracellular matrix remodeling; morphogenesis; tissue architecture; matrix metalloproteinases; microscopy and image processing; zebrafish

Special Issue Information

Dear Colleagues,

The emergence of functional tissue architecture, and the dramatic changes in tissue structure that occur during embryonic morphogenesis, require dynamic remodelling of the extracellular matrix (ECM). Yet our understanding of how cellular activities bring about these changes, how these activities are regulated, and how these regulatory mechanisms have evolved remain frustratingly vague. This Special Issue will focus on new data and novel insights into the remodelling of the extracellular matrix occurring during embryonic development, with emphasis on the underlying molecular mechanisms. We especially encourage submission of studies elucidating activities and regulation of ECM remodelling effectors in vivo, and investigations based on a broad phylogenetic perspective. Both research and review papers are welcome. The objective of this Special Issue is to contribute significantly to a coherent model of how genetically programmed cellular activity cooperatively give rise to meso- and macroscopic tissue organization.

Prof. Dr. Bryan D. Crawford
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Developmental Biology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Extracellular matrix
  • Matrix remodeling
  • Morphogenesis
  • MMPs
  • ADAMS
  • TIMPs
  • Adhesion
  • Biomechanics
  • Cell migration and pathfinding
  • Sequestered signaling molecules

Published Papers (2 papers)

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Research

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Open AccessArticle
Pectoral Fin Anomalies in tbx5a Knockdown Zebrafish Embryos Related to the Cascade Effect of N-Cadherin and Extracellular Matrix Formation
J. Dev. Biol. 2019, 7(3), 15; https://doi.org/10.3390/jdb7030015 - 12 Jul 2019
Abstract
Functional knockdown of zebrafish tbx5a causes hypoplasia or aplasia of pectoral fins. This study aimed to assess developmental pectoral fin anomalies in tbx5a morpholino knockdown zebrafish embryos. The expression of cartilage-related genes in the tbx5a morphant was analyzed by DNA microarray, immunostaining, and [...] Read more.
Functional knockdown of zebrafish tbx5a causes hypoplasia or aplasia of pectoral fins. This study aimed to assess developmental pectoral fin anomalies in tbx5a morpholino knockdown zebrafish embryos. The expression of cartilage-related genes in the tbx5a morphant was analyzed by DNA microarray, immunostaining, and thin-section histology to examine the detailed distribution of the extracellular matrix (ECM) during different pectoral fin developmental stages. Chondrogenic condensation (CC) in the tbx5a morpholino knockdown group was barely recognizable at 37 h postfertilization (hpf); the process from CC to endoskeleton formation was disrupted at 48 hpf, and the endoskeleton was only loosely formed at 72 hpf. Microarrays identified 18 downregulated genes in tbx5a-deficient embryos, including 2 fin morphogenesis-related (cx43, bbs7), 4 fin development-related (hoxc8a, hhip, axin1, msxb), and 12 cartilage development-related (mmp14a, sec23b, tfap2a, slc35b2, dlx5a, dlx1a, tfap2b, fmr1, runx3, cdh2, lect1, acvr2a, mmp14b) genes, at 24 and 30 hpf. The increase in apoptosis-related proteins (BAD and BCL2) in the tbx5a morphant influenced the cellular component of pectoral fins and resulted in chondrocyte reduction throughout the different CC phases. Furthermore, tbx5a knockdown interfered with ECM formation in pectoral fins, affecting glycosaminoglycans, fibronectin, hyaluronic acid (HA), and N-cadherin. Our results provide evidence that the pectoral fin phenotypic anomaly induced by tbx5a knockdown is related to disruption of the mesoderm and ECM, consequently interfering with mesoderm migration, CC, and subsequent endoskeleton formation. Full article
(This article belongs to the Special Issue Matrix Remodelling during Development)
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Review

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Open AccessReview
A Potential Role for MMPs during the Formation of Non-Neurogenic Placodes
J. Dev. Biol. 2018, 6(3), 20; https://doi.org/10.3390/jdb6030020 - 26 Jul 2018
Cited by 1
Abstract
The formation of non-neurogenic placodes is critical prior to the development of several epithelial derivatives (e.g., feathers, teeth, etc.) and their development frequently involves morphogenetic proteins (or morphogens). Matrix metalloproteinases (MMPs) are important enzymes involved in extracellular matrix remodeling, and recent research has [...] Read more.
The formation of non-neurogenic placodes is critical prior to the development of several epithelial derivatives (e.g., feathers, teeth, etc.) and their development frequently involves morphogenetic proteins (or morphogens). Matrix metalloproteinases (MMPs) are important enzymes involved in extracellular matrix remodeling, and recent research has shown that the extracellular matrix (ECM) can modulate morphogen diffusion and cell behaviors. This review summarizes the known roles of MMPs during the development of non-neurogenic structures that involve a placodal stage. Specifically, we discuss feather, hair, tooth, mammary gland and lens development. This review highlights the potential critical role MMPs may play during placode formation in these systems. Full article
(This article belongs to the Special Issue Matrix Remodelling during Development)
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