Optimizing Treatment Outcomes in Sickle Cell Disease
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 197
Special Issue Editor
Interests: sickle cell disease with a focus on pediatric care and outcomes; infant screening; heterogeneity of treatment outcomes; treatment adherence; effects on the brain; and treatment outcomes in global settings
Special Issue Information
Dear Colleagues,
Sickle cell disease (SCD) adversely impacts communities on most continents, especially in under-resourced regions of sub-Saharan Africa and India. An increased number of successful treatment trials have led to increasing clinical therapeutic options. Some therapies are more effective, or confer a more favorable risk–benefit ratio, for the more severe genotypes of SCD, leaving the generally milder forms with limited or under-informed options. Key issues in optimizing outcomes include aligning treatment targets between people living with the disease and their care providers, e.g., ameliorating pain episodes, improving anemia, quality of life and mortality, limiting cost; identifying biomarkers, e.g., SCD types and/or genomic markers, to predict the impact of specific interventions to inform treatment decisions; addressing barriers to treatment implementation and adherence; addressing limits to treatment accessibility across high-, middle-, and low-resource regions. Treatments need to be paired with the uptake of standard preventative measures. These issues must be addressed in order to realize optimal treatment outcomes for SCD.
Dr. Nancy S. Green, MD
Guest Editor
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Keywords
- Sickle cell disease
- Sickle cell anemia
- therapeutic trials
- treatment targets
- treatment options
- treatment uptake
- treatment adherence
- treatment implementation
- treatment optimization
- global treatment access
- barriers to care
- quality of life
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