Steroidomics for the Prevention, Assessment, and Management of Cancers

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 3833

Special Issue Editors


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Guest Editor
College of Pharmacy, Seoul National University, Seoul 08826, Korea
Interests: clinical medicine; translational medicine; multi-omics; cancer; biochemical analysis

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Guest Editor
Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea
Interests: human cancers and neurological diseases; omics sciences; systems medicine; medical ecology and environmental pollution research
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Special Issue Information

Dear Colleagues,

Years of research have suggested that steroidogenesis, androgen and estrogen metabolism, and androstenedione metabolism, among others, are associated with human cancer. Mass spectrometry-based approaches are currently the method of choice to accurately analyze steroids from various biological matrices. High-throughput profiling and quantification of steroids, steroidomics, is an emerging field that has profound potential for the prevention, assessment, and management of human cancer. Nevertheless, there are still rooms for improvement to facilitate the employment of steroidomics in clinical research. These include, but not limited to, the study design, sample logistics, instrumental analysis, post-analytic data processing, and statistical analysis. This special issue aims at highlighting recent advances in clinical steroidomics, which an emphasis on the prevention, assessment, and management of human cancers. We consider all original research articles and review papers that support the advancement of clinical steroidomics as an independent field or as a member of the omics family. In particular, we will focus on the development of state-of-the-art analytical approaches, bioinformatics, statistical learning in addition to critical clinical aspects such as study design and tissue-specific steroidome of cancer. Studies of which the employment of steroidomics for the elucidation of the mechanism and etiology of cancer are also welcome.

Prof. Dr. Sung Won Kwon
Dr. Nguyen Phuoc Long
Guest Editors

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Keywords

  • steroidomics
  • metabolomics
  • lipidomics
  • multi-omics
  • clinical research
  • cancer
  • biomarker
  • prevention
  • diagnosis
  • prognosis

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Published Papers (1 paper)

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Research

14 pages, 1383 KiB  
Article
Impact of Serum Lipid on Breast Cancer Recurrence
by Sung Mi Jung, Danbee Kang, Eliseo Guallar, Jonghan Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Juhee Cho and Se Kyung Lee
J. Clin. Med. 2020, 9(9), 2846; https://doi.org/10.3390/jcm9092846 - 2 Sep 2020
Cited by 26 | Viewed by 3384
Abstract
The association between serum lipid level and prognosis of breast cancer is controversial. The purpose of this study was to evaluate the impact of serum lipid level in breast cancer recurrence. We analyzed a total of 4190 patients with operable breast cancer who [...] Read more.
The association between serum lipid level and prognosis of breast cancer is controversial. The purpose of this study was to evaluate the impact of serum lipid level in breast cancer recurrence. We analyzed a total of 4190 patients with operable breast cancer who had baseline serum lipid profiles; total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), apolipoprotein A-1, and apolipoprotein B. Recurrence-free survival is defined as the elapsed time from the date of curative surgery to the detection of any recurrence, and recurrence includes locoregional recurrence, distant metastasis, or both local and distant metastasis. Cox-proportional hazard analysis was used to estimate hazard ratios with 95% confidence intervals (CI) for study outcomes comparing the three lowest quartiles of each lipid parameter to the highest quartile adjusting for age, body mass index (BMI), and pathologic stage, estrogen receptor (ER), progesterone receptor (PR), comorbidities (hypertension, diabetes, or vascular event) at time of breast cancer diagnosis. Patients with dyslipidemia (high bad cholesterol and low good cholesterol level) had worse prognostic factors (i.e., negative hormone receptor status, positive human epidermal growth factor receptor 2 (HER2) expression, higher nuclear grade). After adjusting for these poor prognostic factors, the patients with dyslipidemia showed good prognosis for breast cancer recurrence. Our study showed that baseline high lipid level could be a good prognostic factor of breast cancer. This study indicates that desirable changes in lipid profile for cardiovascular disease risk are not always beneficial for patients with breast cancer. However, as proper control of lipid level has advantages for cardiovascular disease, these findings require careful interpretation. Full article
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