Impact of Serum Lipid on Breast Cancer Recurrence
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Measurements
2.3. Statistical Analysis
3. Results
3.1. Patients Characteristics
3.2. Prognostic Role of Lipid Profile with Regard to Disease Recurrence in Breast Cancer Patients
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Overall (N = 4190) | |
---|---|
N (%) | |
Age, mean (SD) | 51.7 (9.8) |
BMI, mean (SD) | 23.6 (3.2) |
Blood lab, mean (SD) | |
Total cholesterol (110–240) (mg/dL) | 193.3 (33.7) |
Triglyceride (50–200) (mg/dL) | 102.8 (61.4) |
HDL cholesterol (45–65) (mg/dL) | 59.9 (14.8) |
LDL cholesterol (40–130) (mg/dL) | 119.4 (29.8) |
TG/HDL | 2.0 (1.7) |
Non-HDL cholesterol | 133.4 (33.7) |
Menopausal status | |
Yes | 2217 (52.9) |
No | 1962 (46.8) |
Unknown | 11 (0.3) |
Comorbidity (n = 2946) * | |
No | 2310 (78.4) |
Yes | 636 (21.6) |
Surgery type (n = 4188) | |
>Mastectomy | 1166 (27.8) |
BCS | 3022 (72.2) |
Stage | |
I | 2050 (48.9) |
II | 1679 (40.1) |
III | 461 (11.0) |
ER | |
Positive | 3155 (75.3) |
Negative | 1032 (24.6) |
Unknown | 3 (0.1) |
PR | |
Positive | 2894 (69.1) |
Negative | 1293 (30.9) |
Unknown | 3 (0.1) |
HER2 | |
Positive | 842 (20.1) |
Negative | 3275 (78.2) |
Unknown | 73 (1.7) |
Subtype | |
Luminal A | 2737 (65.3) |
Luminal B | 406 (9.7) |
HER2 type | 436 (10.4) |
TNBC | 538 (12.8) |
Unknown | 73 (1.7) |
LVI | |
No | 3018 (72.0) |
Yes | 1149 (27.4) |
Unknown | 23 (0.6) |
Multiplicity | |
No | 3274 (78.1) |
Yes | 913 (21.8) |
Unknown | 3 (0.1) |
Nuclear grade | |
Low | 847 (20.2) |
Intermediate | 1942 (46.4) |
High | 1393 (33.3) |
Unknown | 8 (0.2) |
Chemotherapy | |
No | 1532 (36.6) |
Yes | 2586 (61.7) |
Unknown | 72 (1.7) |
Radiotherapy | |
No | 882 (21.1) |
Yes | 3205 (76.5) |
Unknown | 103 (2.5) |
Hormone therapy | |
No | 781 (18.6) |
Yes | 3409 (81.4) |
AI ‡ | 1439 (34.3) |
SERM § | 1887 (45.0) |
Patients with Events | Crude | Adjusted | |||
---|---|---|---|---|---|
Hazard Ratio | p-Value | Hazard Ratio | p-Value | ||
(95% CI) | (95% CI) | ||||
Total cholesterol | |||||
Quartile I | 34 | 1.49 (0.89, 2.48) | 0.13 | 1.34 (0.78, 2.30) | 0.28 |
Quartile II | 29 | 1.18 (0.70, 2.01) | 0.54 | 1.14 (0.66, 1.96) | 0.63 |
Quartile III | 36 | 1.60 (0.96, 2.65) | 0.07 | 1.47 (0.88, 2.45) | 0.14 |
Quartile IV | 26 | Reference | Reference | ||
LDL cholesterol | |||||
Quartile I | 33 | 1.68 (0.97, 2.90) | 0.06 | 1.71 (0.96, 3.06) | 0.07 |
Quartile II | 35 | 1.72 (0.99, 2.95) | 0.05 | 1.62 (0.92, 2.83) | 0.09 |
Quartile III | 36 | 1.88 (1.09, 3.22) | 0.02 | 1.88 (1.09, 3.27) | 0.02 |
Quartile IV | 21 | Reference | Reference | ||
HDL cholesterol | |||||
Quartile I | 33 | 0.58 (0.37, 0.93) | 0.02 | 0.54 (0.33, 0.88) | 0.01 |
Quartile II | 33 | 0.65 (0.41, 1.04) | 0.07 | 0.59 (0.37, 0.96) | 0.03 |
Quartile III | 20 | 0.43 (0.25, 0.75) | <0.001 | 0.45 (0.26, 0.77) | < 0.01 |
Quartile IV | 39 | Reference | Reference | ||
Triglyceride | |||||
Quartile I | 34 | 1.75 (0.05, 2.93) | 0.03 | 1.88 (1.07, 3.29) | 0.03 |
Quartile II | 34 | 1.55 (0.93, 2.59) | 0.09 | 1.66 (0.97, 2.82) | 0.06 |
Quartile III | 31 | 1.36 (0.81, 2.29) | 0.25 | 1.32 (0.78, 2.25) | 0.31 |
Quartile IV | 26 | Reference | Reference | ||
TG/HDL | |||||
Quartile I | 32 | 1.59 (0.95, 2.64) | 0.08 | 1.82 (1.04, 3.21) | 0.04 |
Quartile II | 30 | 1.40 (0.83, 2.35) | 0.21 | 1.57 (0.91, 2.73) | 0.11 |
Quartile III | 35 | 1.43 (0.87, 2.35) | 0.16 | 1.45 (0.87, 2.42) | 0.16 |
Quartile IV | 28 | Reference | Reference | ||
Non-HDL cholesterol | |||||
Quartile I | 31 | 1.41 (0.85, 2.35) | 0.19 | 1.53 (0.89, 2.66) | 0.13 |
Quartile II | 32 | 1.37 (0.83, 2.28) | 0.22 | 1.45 (0.85, 2.48) | 0.17 |
Quartile III | 34 | 1.47 (0.89, 2.43) | 0.13 | 1.55 (0.92, 2.61) | 0.10 |
Quartile IV | 28 | Reference | Reference |
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Share and Cite
Jung, S.M.; Kang, D.; Guallar, E.; Yu, J.; Lee, J.E.; Kim, S.W.; Nam, S.J.; Cho, J.; Lee, S.K. Impact of Serum Lipid on Breast Cancer Recurrence. J. Clin. Med. 2020, 9, 2846. https://doi.org/10.3390/jcm9092846
Jung SM, Kang D, Guallar E, Yu J, Lee JE, Kim SW, Nam SJ, Cho J, Lee SK. Impact of Serum Lipid on Breast Cancer Recurrence. Journal of Clinical Medicine. 2020; 9(9):2846. https://doi.org/10.3390/jcm9092846
Chicago/Turabian StyleJung, Sung Mi, Danbee Kang, Eliseo Guallar, Jonghan Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Juhee Cho, and Se Kyung Lee. 2020. "Impact of Serum Lipid on Breast Cancer Recurrence" Journal of Clinical Medicine 9, no. 9: 2846. https://doi.org/10.3390/jcm9092846