Acute Ischemic Stroke: Current Status and Future Challenges—2nd Edition
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".
Deadline for manuscript submissions: 20 May 2026 | Viewed by 1283
Special Issue Editor
2. Department of Brain Sciences, Imperial College London, London SW7 2AZ, UK
Interests: stroke; cryptogenetic stroke; atrial fibrillation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Following the success of the first volume of this Special Issue (https://www.mdpi.com/si/195695), we decided to launch a second volume to discuss a greater number of relevant topics.
Stroke is a leading cause of mortality and the primary cause of disability worldwide, with ischemic stroke accounting for approximately 70% of all cases globally. Acute stroke treatment has enjoyed 2 major successes over the past 30 years, both involving early reperfusion of the ischemic brain. Both thrombolytic drug treatment and endovascular thrombectomy, after some initial stutters, hit upon successful strategies for patient selection and trial design that yielded a large treatment effect compared with control groups. Recent advancements in brain imaging techniques have significantly expanded the treatment window for reperfusion therapies in carefully selected patients, resulting in improved functional outcomes in the short and long term. Despite significant advancements, several controversies persist in the field of ischemic stroke management. These controversies encompass various topics, including determining the actual effectiveness of endovascular thrombectomy in patients with large ischemic core, distal vessel occlusion, mild stroke syndromes, or high baseline disability, as well as the safety of intravenous thrombolysis in patients with recent ingestion of direct oral anticoagulants. Moreover, these controversies include various topics, including determining the optimal secondary prevention strategies. By examining the latest evidence in ischemic stroke management, this research topic aims to explore recent advancements, challenges, and ongoing debates throughout the entire spectrum of ischemic stroke management, including prevention strategies, diagnostic techniques, and acute treatment approaches. The studies included in this research endeavor will contribute to the ongoing efforts to enhance clinical practice, improve patient outcomes, and guide the future direction of stroke care.
This Special Issue welcomes original research and reviews.
Dr. Lucio D'Anna
Guest Editor
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Keywords
- acute ischemic stroke
- atrial fibrillation
- endovascular thrombectomy
- intravenous thrombolysis
- direct oral anticoagulants
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