Special Issue "Pathogenesis, Clinical Diagnosis, Treatments and Managements of Systemic Sclerosis"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editor

Prof. Dr. Shinichi Sato
Guest Editor
Department of Dermatology, University of Tokyo, Tokyo, Japan
Interests: scleroderma; B lymphocytes; autoimmunity

Special Issue Information

Dear Colleagues,

Systemic sclerosis (SSc) is a connective tissue disorder characterized by fibrosis in the skin and internal organs. Although the pathogenesis of SSc remains unknown, collagen accumulation, vascular damage, and abnormal immune activation are major abnormalities. In particular, since immunosuppresants are effective for fibrosis in SSc, abnormal immune regulation is considered to be most important. However, understanding the pathogenesis from other perspectives, such as fibroblast and vascular endothelial cell abnormalities, is equally important. There are also many points to be solved clinically. For example, since interstitial lung disease associated with SSc does not progress in all patients, how do we identify the interstitial lung disease that will progress in the future? The purpose of this Special Issue is to understand the pathogenesis of SSc and to provide the latest knowledge on important clinical issues. Therefore, researchers in the field of SSc are encouraged to submit an original article or review to this Special Issue.

Prof. Dr. Shinichi Sato
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • immune activation
  • fibroblast activation
  • vascular abnormality
  • diagnosis
  • natural course
  • biomarker
  • therapy
  • clinical study
  • primary endpoint

Published Papers

This special issue is now open for submission.
Back to TopTop