Special Issue "New Opportunities and Challenges of Early Psychosis"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Psychiatry".

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editor

Prof. Dr. Marta Rapado-Castro
Guest Editor
1. Ramón y Cajal Senior Research Fellow, Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.
2. Assistant Professor, Department of Legal Medicine, Psychiatry and Patology (Psychiatry Area), School of Medicine, Universidad Complutense, Madrid, Spain.
Interests: Psychotic Disorders; Prodrome; Neurocognition; Risk factors; Diagnosis; Biomarkers; Neuroimaging; Early life adversity; Cognitive-enhancers; Early Intervention

Special Issue Information

Dear Colleagues,

Over the past two decades, the early psychosis field has advanced and expanded substantially. A great deal of progress has been made understanding phenomenology, neurobiology and outcome during early phase of psychotic disorders. Although there is extensive investigation of early signs of risk and evidence-based treatments, psychotic disorders continue to severely affect both young and adults. Schizophrenia and other psychotic disorders represent the third leading cause of disability-adjusted life years worldwide. Early diagnosis and treatment of first-episode psychosis is crucial for short and long-term prognosis. Delayed identification of symptoms and a longer duration of untreated psychosis may lead to challenges in functional and clinical outcomes. Effective and timely interventions have shown to improve psychopathology, quality of life and vocational development of individuals with psychosis. With major unmet needs such as cognitive and negative symptoms, early psychosis research still faces several conceptual, methodological and treatment challenges. In this Special Issue, we will focus on recent advances in understanding and treating the early phase of psychotic disorders, as well as some of the challenges to furthering the application of a broader preventive model.

Qualitative and quantitative original research or reviews of current knowledge in the early psychosis field are welcomed.

Prof. Dr. Marta Rapado-Castro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • First-Episode Psychosis
  • Prodrome
  • Risk Factors
  • Biomarkers
  • Prognosis
  • Early Detection
  • Early Intervention
  • Clinical Outcomes
  • Functional outcomes
  • Neuroimaging
  • Neurocognition
  • Diagnosis
  • Novel treatments

Published Papers (1 paper)

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Open AccessArticle
Exploring Risk and Resilient Profiles for Functional Impairment and Baseline Predictors in a 2-Year Follow-Up First-Episode Psychosis Cohort Using Latent Class Growth Analysis
J. Clin. Med. 2021, 10(1), 73; https://doi.org/10.3390/jcm10010073 - 28 Dec 2020
Being able to predict functional outcomes after First-Episode Psychosis (FEP) is a major goal in psychiatry. Thus, we aimed to identify trajectories of psychosocial functioning in a FEP cohort followed-up for 2 years in order to find premorbid/baseline predictors for each trajectory. Additionally, [...] Read more.
Being able to predict functional outcomes after First-Episode Psychosis (FEP) is a major goal in psychiatry. Thus, we aimed to identify trajectories of psychosocial functioning in a FEP cohort followed-up for 2 years in order to find premorbid/baseline predictors for each trajectory. Additionally, we explored diagnosis distribution within the different trajectories. A total of 261 adults with FEP were included. Latent class growth analysis identified four distinct trajectories: Mild impairment-Improving trajectory (Mi-I) (38.31% of the sample), Moderate impairment-Stable trajectory (Mo-S) (18.39%), Severe impairment-Improving trajectory (Se-I) (12.26%), and Severe impairment-Stable trajectory (Se-S) (31.03%). Participants in the Mi-I trajectory were more likely to have higher parental socioeconomic status, less severe baseline depressive and negative symptoms, and better premorbid adjustment than individuals in the Se-S trajectory. Participants in the Se-I trajectory were more likely to have better baseline verbal learning and memory and better premorbid adjustment than those in the Se-S trajectory. Lower baseline positive symptoms predicted a Mo-S trajectory vs. Se-S trajectory. Diagnoses of Bipolar disorder and Other psychoses were more prevalent among individuals falling into Mi-I trajectory. Our findings suggest four distinct trajectories of psychosocial functioning after FEP. We also identified social, clinical, and cognitive factors associated with more resilient trajectories, thus providing insights for early interventions targeting psychosocial functioning. Full article
(This article belongs to the Special Issue New Opportunities and Challenges of Early Psychosis)
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