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Management of Ligaments and Tendons Injuries
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Management of Ligaments and Tendons Injuries

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1833

Special Issue Editor

Dr. Vivek Kumar Morya

E-Mail Website
Guest Editor
Hallym University Dongtan Sacred Heart Hospital, Hwaseong-si 18450, Republic of Korea
Interests: tendinopathy; ligaments; tendons

Special Issue Information

Dear Colleagues,

Ligaments and tendons are crucial connective tissues that ensure joint stability and coordinated movement. Injuries to these structures—such as anterior cruciate ligament (ACL) tears or rotator cuff tendinopathy—are increasingly prevalent among athletes, physically active individuals, and even the general population due to trauma or repetitive stress.

Managing ligament and tendon injuries remains a clinical challenge, necessitating precise diagnosis, individualized treatment planning, and optimized rehabilitation strategies. This Special Issue aims to present recent advancements and evidence-based approaches across the continuum of care—from innovative diagnostic modalities to novel surgical techniques, biologic therapies, and post-operative rehabilitation.

By uniting perspectives from orthopedic surgeons, sports medicine experts, rehabilitation specialists, and translational researchers, this Special Issue aspires to foster interdisciplinary dialogue and improve the clinical outcomes of patients suffering from these complex musculoskeletal injuries.

Dr. Vivek Kumar Morya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tendinopathy
  • ligaments
  • tendons
  • anterior cruciate ligament (ACL)
  • rotator cuff

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Published Papers (2 papers)

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Research

11 pages, 785 KB  
Article
Resolvin E1 as a Potential Biomarker of Tendon Retraction Severity in Rotator Cuff Tears
by Recep Taskin, Sedat Gülten, Mehmet Akif Bildirici and Osman Sabri Kesbiç
J. Clin. Med. 2025, 14(24), 8887; https://doi.org/10.3390/jcm14248887 - 16 Dec 2025
Abstract
Background/Objectives: Specialized pro-resolving lipid mediators (SPMs), such as Resolvin E1 (RvE1) and Resolvin D1 (RvD1), play a critical role in the resolution phase of inflammation. However, their relevance to tendon pathology and tissue-specific degeneration in rotator cuff tears remains unclear. This study [...] Read more.
Background/Objectives: Specialized pro-resolving lipid mediators (SPMs), such as Resolvin E1 (RvE1) and Resolvin D1 (RvD1), play a critical role in the resolution phase of inflammation. However, their relevance to tendon pathology and tissue-specific degeneration in rotator cuff tears remains unclear. This study aimed to investigate the relation between serum RvE1 and RvD1 levels and the morphological severity of tendon retraction and muscle fatty degeneration in patients with full-thickness rotator cuff tears. Methods: A total of 70 participants were included: 35 patients with full-thickness rotator cuff tears determined by magnetic resonance imaging (MRI) and 35 healthy controls. Tendon retraction and muscle fatty degeneration were graded using Patte and Goutallier classifications, respectively. Serum RvE1 and RvD1 levels were measured using enzyme-linked immunosorbent assay (ELISA). Group comparisons were performed using Welch’s t-test, and correlations were analyzed with Spearman’s coefficient. Results: RvE1 and RvD1 levels were significantly lower in patients compared to controls (p < 0.001). RvE1 showed a moderate positive correlation with Patte score (ρ = 0.37, p = 0.027), while no significant correlation was observed with Goutallier classification (ρ = 0.19, p = 0.27). RvD1 levels demonstrated no significant relationship with either morphological parameter. Conclusions: These findings suggest that decreased serum RvE1 levels are associated with the severity of tendon retraction but not with muscle fatty degeneration. Therefore, RvE1 may serve as a potential biochemical biomarker reflecting tendon damage severity and the impaired resolution of inflammation in rotator cuff tears. Full article
(This article belongs to the Special Issue Management of Ligaments and Tendons Injuries)
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15 pages, 1093 KB  
Article
Effectiveness of Ultrasound-Guided Peritendinous Injection Treatment with Low Molecular Weight Hyaluronic Acid in Patients with Supraspinatus Tendinopathy
by Francesco Agostini, Alessandro de Sire, Alessio Savina, Giovanni Iudicelli, Andrea Fisicaro, Giacomo Camponogara, Marco Narciso, Alessio Fricano, Marco Conti, Umile Giuseppe Longo, Valter Santilli, Antonio Ammendolia, Massimiliano Mangone and Marco Paoloni
J. Clin. Med. 2025, 14(17), 6291; https://doi.org/10.3390/jcm14176291 - 5 Sep 2025
Cited by 1 | Viewed by 1582
Abstract
Background/Objectives: Tendinopathies represent a prevalent musculoskeletal condition characterized by load-dependent pain, stiffness, weakness, and impaired functionality. Current treatment includes therapeutic exercise, physical modalities and injective therapy. Hyaluronic acid (HA) is a fundamental component of the extracellular matrix and plays a crucial role [...] Read more.
Background/Objectives: Tendinopathies represent a prevalent musculoskeletal condition characterized by load-dependent pain, stiffness, weakness, and impaired functionality. Current treatment includes therapeutic exercise, physical modalities and injective therapy. Hyaluronic acid (HA) is a fundamental component of the extracellular matrix and plays a crucial role in tissue hydration, elasticity, and lubrication. This study aims to evaluate the effectiveness of ultrasound-guided injections of HA in improving pain symptoms and functionality in patients with supraspinatus tendinopathy. Methods: Patients with a confirmed diagnosis of supraspinatus tendinopathy, verified through ultrasound imaging, were included in the study. Patients underwent 3 ultrasound guidance injections (1/week) of Sodium Hyaluronate (Hyalotend, 20 mg/2 mL). Patients were evaluated at the baseline, 1 month (T1), 3 months (T2), 6 months (T3), and 1 year (T4) after the first injection through the VAS, the QuickDASH and the SF-12. Results: Twenty-four patients were enrolled. As regards the VAS there was a statistically significant reduction (p < 0.01) of averages of values over time. The scores collected through the QuickDASH questionnaire have a statistically significant variation over time (p < 0.001). The values collected through the SF-12 Mental Component Summary (MCS) questionnaire show a highly statistically significant variation over time (p < 0.005). The values collected through the SF-12 Physical Component Summary (PCS) questionnaire show a statistically highly significant change over time (p < 0.001). Conclusions: Our results suggest that HA (Hyalotend) injections could represent a viable therapeutic option for patients with supraspinatus tendinopathy in the short, medium, and long term. Further studies with larger patient samples and a control group are needed to better investigate the effects and the modalities of administration of HA in tendinopathies. Full article
(This article belongs to the Special Issue Management of Ligaments and Tendons Injuries)
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