Clinical Role of Neuroinflammation in Disease
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".
Deadline for manuscript submissions: closed (10 April 2025) | Viewed by 1842
Special Issue Editor
2. Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, 113 Street 87 Avenue, Edmonton, AB T6G 2E1, Canada
3. Department of Oncology, Faculty of Medicine & Dentistry, University of Alberta, 113 Street 87 Avenue, Edmonton, AB T6G 2E1, Canada
4. BioImmuno Designs, 4747 154 Avenue, Edmonton, AB T5Y 0C2, Canada
Interests: inflammation; cancer; drug discovery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroinflammation is defined as the inflammation of brain tissues. It is activated in response to many signals and helps to protect the brain tissues from injury. Primary abnormalities that arise because of the presence of neuroinflammation in the brain include Parkinson’s Disease, Alzheimer’s Disease (AD), multiple sclerosis, amyotrophic lateral sclerosis (ALS) and encephalitis, to mention but a few. In addition, it is well documented that persistent neuroinflammation in traumatic brain injury can lead to neurological disorders such as epilepsy, encephalopathy and AD. In the past ten years, systemic inflammation (and specifically colonic inflammation) has been demonstrated to promote neuroinflammation in the well-known concept of the “gut–brain axis”. Lastly, autoimmune disorders can also trigger neuroinflammation, resulting in several co-morbidities linked to brain inflammation.
Specific therapeutics to control systemic inflammation are varied and lacking for neuroinflammation. We are only just beginning to understand the molecular drivers of inflammation (systemic and neuronal inflammation), how they are linked to altered metabolism and proliferation and what biomarkers are important in tracking the appearance and progression of inflammation. This Special Issue will illustrate original work and reviews describing the molecular details of neuroinflammation, emerging therapeutic interventions and potential clinical use, with the aim of expanding our understanding of neuroinflammation.
Dr. Shairaz Baksh
Guest Editor
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Keywords
- neuroinflammation
- brain tissues
- Parkinson's Disease
- Alzheimer's Disease
- multiple sclerosis
- amyotrophic lateral sclerosis
- encephalitis
- traumatic brain injury
- epilepsy
- encephalopathy
- systemic inflammation
- colonic inflammation
- gut-brain axis
- autoimmune disorders
- therapeutics
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