Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.7
3.0
Journals
JCM
Special Issues
Alopecia Areata: From Diagnosis to Treatment
jcm-logo
Submit to JCM Review for JCM Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Alopecia Areata: From Diagnosis to Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 8248

Special Issue Editors

Dr. Gemma Caro

E-Mail
Guest Editor
Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy
Interests: trichology; trichoscopy; hair; alopecia areata; acne vulgaris; scalp psoriasis; oncodermatology
Prof. Dr. Alfredo Rossi

E-Mail
Guest Editor
Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy
Interests: tricology; tricoscopy; hair loss; alopecia areata; seborrheic dermatitis; androgenetic alopecia; psoriasis
Dr. Michela Starace

E-Mail Website
Guest Editor
1. Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
2. Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy
Interests: alopecia; hair loss; nail; hair; alopecia areata; cicatricial alopecia; nail tumors; onychomycosis; scaling

Special Issue Information

Dear Colleagues,

Alopecia areata (AA) has been receiving increasing scientific attention in recent years. The reports of AA onset and reacutization after COVID-19 infection and vaccination shed new light on the pathogenesis of this disease and its possible triggers and worsening factors. Moreover, the introduction of Janus kinase (JAK) as a new effective treatment paved the way for a new therapeutic era for a disease whose therapies were often off-label and not always satisfactory. Nevertheless, this is just the beginning and there is still a lot to know about the mechanisms underlying AA, about how new therapies work and how they can give the best results. In this view, old and new diagnostic tools will be crucial for identifying the different pathogenic moments and for monitoring therapeutic progress.

In this Special Issue, we welcome authors to submit papers on any aspect of alopecia areata in order to be part of a new chapter of the story of this disease and to help improve the quality of life of affected patients.

Dr. Gemma Caro
Prof. Dr. Alfredo Rossi
Dr. Michela Starace
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • alopecia areata
  • alopecia totalis
  • alopecia universalis
  • JAK inhibitors
  • trichoscopy
  • JAK-STAT signaling pathway
  • quality of life

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

12 pages, 2395 KiB  
Article
Subclinical Atherosclerosis in Alopecia Areata: Usefulness of Arterial Ultrasound for Disease Diagnosis and Analysis of Its Relationship with Cardiometabolic Parameters
by Patricia Burgos-Blasco, Alvaro Gonzalez-Cantero, Angela Hermosa-Gelbard, Juan Jiménez-Cahue, Diego Buendía-Castaño, Emilio Berna-Rico, Carlota Abbad-Jaime de Aragón, Sergio Vañó-Galván and David Saceda-Corralo
J. Clin. Med. 2024, 13(14), 4264; https://doi.org/10.3390/jcm13144264 - 22 Jul 2024
Viewed by 1592
Abstract
Background/Objectives: Chronic systemic inflammation is a risk factor that increases the development of atherosclerosis and predisposes to cardiovascular diseases (CVDs). The systemic inflammatory profile of alopecia areata (AA) regarding IFNγ and Th1 cytokine dysregulation has previously been described, suggesting an increased incidence of [...] Read more.
Background/Objectives: Chronic systemic inflammation is a risk factor that increases the development of atherosclerosis and predisposes to cardiovascular diseases (CVDs). The systemic inflammatory profile of alopecia areata (AA) regarding IFNγ and Th1 cytokine dysregulation has previously been described, suggesting an increased incidence of CVDs in this population. No previous studies investigated the possible relationship between atherosclerosis and AA by cardiovascular imaging techniques. To determine the prevalence, distribution and burden of subclinical atherosclerosis in AA. Methods: We conducted a case–control study in 62 participants, including 31 patients with severe AA (SALT > 75) and 31 healthy controls, matched for age, sex and body mass index (BMI). The participants underwent a detailed history assessment and were subjected to the measurement of weight, height, abdominal circumference and blood pressure. A fasting blood sample was also collected. Subclinical atherosclerosis was evaluated by ultrasonography of the bilateral femoral and carotid arteries. Results: The AA patients had an increased prevalence of subclinical atherosclerosis (54.7%) compared to the healthy controls (22.6%, p = 0.010). The prevalence of atheroma plaques was significantly higher in the carotid arteries (41.90% vs. 12.9%, p = 0.009), while no significant differences were found in femoral plaque prevalence. The AA patients with atherosclerotic plaques were older (p < 0.001) and had a longer time since AA diagnosis (p = 0.11) and increased serum levels of glycated hemoglobin (p = 0.029) and triglycerides (p = 0.009). In a regression analysis, duration of disease and neutrophil/lymphocyte ratio were the main predictors of atherosclerosis. Conclusions: AA patients have an increased prevalence of carotid subclinical atherosclerosis. The duration of AA, systemic inflammation and insulin resistance appear to play a role in the development of subclinical atherosclerosis in this population. Full article
(This article belongs to the Special Issue Alopecia Areata: From Diagnosis to Treatment)
►▼ Show Figures

Figure 1

9 pages, 1722 KiB  
Article
A New Method for the Follow-Up of Patients with Alopecia Areata
by Giulio Bortone, Gemma Caro, Lorenzo Ala, Luca Gargano and Alfredo Rossi
J. Clin. Med. 2024, 13(13), 3901; https://doi.org/10.3390/jcm13133901 - 3 Jul 2024
Cited by 1 | Viewed by 1382
Abstract
Background: Teledermatology is the application of information and telecommunication technologies in the field of dermatology to provide remote care services based on the exchange of clinical information within a network of professionals or between professionals and patients. Tele-trichoscopy is a non-invasive, inexpensive, and [...] Read more.
Background: Teledermatology is the application of information and telecommunication technologies in the field of dermatology to provide remote care services based on the exchange of clinical information within a network of professionals or between professionals and patients. Tele-trichoscopy is a non-invasive, inexpensive, and easy-to-use method that applies the principle of surface microscopy at different magnifications. Alopecia areata is a non-scarring alopecia with a chronic evolution, which often needs a close follow-up. Objectives: The aim of our work was to analyze the possible benefits of telemedicine for the follow-up of patients with alopecia areata. Materials and Methods: We enrolled patients with alopecia areata, identified during the first trichological evaluation, and we divided the patients into two groups. One group was provided with the devices necessary for a telemedicine follow-up. The other group had a conventional follow-up. The total follow-up time was one year. All of the patients’ photos were blindly evaluated by a team of expert dermatologists who were asked to indicate the quality of the images. The photos were also evaluated to identify disease markers. During the follow-up period, questionnaires were administered to both groups of patients to assess the quality of the visit, the level of patient satisfaction, and to identify any issues encountered by the patients. Results: There was a high degree of concordance between the images obtained by outpatient trichoscopy and those obtained by telemedicine. The satisfaction levels were the same between the patients followed via telemedicine and those seen in the outpatient clinic. Conclusions: Telemedicine applied to trichology using trichoscopy was proven to be a valid system for managing the follow-up of patients suffering from chronic recurrent scalp diseases and, above all, for maintaining continuity of care. Full article
(This article belongs to the Special Issue Alopecia Areata: From Diagnosis to Treatment)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

15 pages, 5917 KiB  
Review
Alopecia Areata of the Nails: Diagnosis and Management
by Christin Pelzer and Matilde Iorizzo
J. Clin. Med. 2024, 13(11), 3292; https://doi.org/10.3390/jcm13113292 - 3 Jun 2024
Cited by 4 | Viewed by 4658
Abstract
Background: Alopecia areata (AA) is a common form of non-scarring alopecia characterized by acute hair loss. Nail involvement, though not always present, can occur in AA patients. Nail changes are more frequent in severe forms of AA and in children. Methods: Literature related [...] Read more.
Background: Alopecia areata (AA) is a common form of non-scarring alopecia characterized by acute hair loss. Nail involvement, though not always present, can occur in AA patients. Nail changes are more frequent in severe forms of AA and in children. Methods: Literature related to nail changes in AA was comprehensively reviewed after a search on the PubMed database without time restrictions in order to identify common clinical presentations and associated factors to aid clinicians with the correct evaluation and management of these dystrophies. Results: Nail changes in AA include pitting, trachyonychia, leukonychia, red lunula, and miscellaneous alterations such as longitudinal ridging and brittle nails. Nail changes are usually asymptomatic but, nevertheless, sometimes cosmetically disfiguring and can be associated with a reduced quality of life and impaired daily activities. Conclusions: Nail changes in AA may precede or follow hair loss and can occur as an isolated finding. Diagnosis may require a biopsy for definitive identification. Spontaneous improvement is possible, particularly in children, and treatment is not always necessary. Further research is, however, needed to establish a consensus on treatment approaches according to age and severity. Full article
(This article belongs to the Special Issue Alopecia Areata: From Diagnosis to Treatment)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop