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Special Issue "Roles of Vascular Oxidative Stress in the Pathogenesis of Atherosclerosis"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Vascular Medicine".

Deadline for manuscript submissions: 20 December 2019

Special Issue Editor

Guest Editor
Dr. Victor M Victor

Researcher FISABIO-Hospital Dr Peset, and Assistant Professor of Physiology, Department of Physiology, University of Valencia, Spain
Website | E-Mail
Phone: (+34) 96.386.46.30
Interests: type 2 diabetes; atherosclerosis; mitochondria; autophagy; oxidative stress; vascular endothelium

Special Issue Information

Dear Colleagues,

It is well known that reactive oxygen species (ROS) and oxidative stress are related to the pathogenesis of atherosclerosis and cardiovascular diseases (CVD). Atherosclerosis represents a state of exacerbated oxidative stress characterized by protein and lipid oxidation in the vascular endothelium. Similarly, endothelial dysfunction is also characterized by a loss of nitric oxide (NO) bioactivity, which occurs early on in the development of atherosclerosis and can determine the development of future vascular complications. In general, ROS are essential to cell functions, including redox signaling, proliferation of cells, and mitogenesis, and can mimic and amplify the action of growth factors; at the same time, adequate levels of antioxidant defenses are required in order to avoid the harmful effects of excessive ROS production.

Therefore, it is clear that the biological specificity of ROS action depends on the localization, amount, and duration of ROS production. To date, although major ROS-sensitive signal transduction pathways have been shown to be involved in atherosclerosis, there is still much to be learned about their mutual interaction and the modifications they undergo during metabolic and vascular diseases, including type 2 diabetes. Due to the relevance of such topics, it would seem appropriate to summarize some of the main recent advances in research on the role of vascular oxidative stress in the pathogenesis of atherosclerosis and its impact on health, disease and aging.
We invite authors to submit original articles and review articles on this interesting topic.
Potential topics include, but are not limited, to the following:

  • Role of ROS in atherosclerosis
  • Type 2 diabetes and atherosclerosis
  • Signaling pathways of ROS action
  • Positive feedback loop in ROS production
  • Interaction among cellular sources of ROS production
  • New insight into the relationship between oxidative stress and atherosclerosis
  • Role of oxidative stress in metabolic, cardiovascular diseases and cancer.
  • Vascular oxidative stress and autophagy-mitophagy
  • Vascular oxidative stress and reticulum stress

Dr. Victor M Victor
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Atherosclerosis
  • Vascular
  • Oxidative stress
  • Mitochondria
  • Mitophagy
  • Autophagy
  • Type 2 diabetes

Published Papers

This special issue is now open for submission.
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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