Special Issue "Epilepsy: Causes, Symptoms, Diagnosis, and Treatment"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 15 July 2023 | Viewed by 447

Special Issue Editor

Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Pisa, Italy
Interests: neurological diseases; brain; neurology; neuroscience; neuroimaging; fMRI; 7 Tesla; EEG; genetics

Special Issue Information

Dear Colleagues,

Epilepsy is a diffuse neurological condition with a remarkable impact on public health. Acknowledging its paramount importance, the 75th World Health Assembly adopted the Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders 2022–2031 (IGAP) on May 27. The incidence of epilepsy follows a U-shaped bimodal distribution, with peaks in early infancy and in the elderly. About 70% of people with epilepsy can enter seizure freedom with treatment. Nevertheless, both diagnostic and treatment gaps exist in every country in the world, and there is a social stigma associated with epilepsy. To optimize epilepsy management, the awareness of the heterogeneous etiologies and of the variable seizure semeiology should be disseminated at the public level.  A shared diagnostic algorithm should be pursued. Advanced neuroimaging and molecular diagnostics may indeed suggest tailored treatment in selected patients, as a precision medicine approach. The present Special Issue aims to collect innovative single reports and case series, critical reviews, out-of-the box viewpoints, and experimental findings focused on the diagnosis, management, and treatment of epilepsy with a focus on the future.

Dr. Emanuele Bartolini
Guest Editor

Manuscript Submission Information

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Keywords

  • neurological diseases
  • brain
  • neurology
  • neuroscience
  • neuroimaging
  • fMRI
  • EEG
  • genetics

Published Papers (1 paper)

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Research

Article
Evaluation of Event-Related Potentials in Assessing Cognitive Functions of Adult Patients with Epilepsy of Unknown Etiology
J. Clin. Med. 2023, 12(7), 2500; https://doi.org/10.3390/jcm12072500 (registering DOI) - 25 Mar 2023
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Abstract
Background: Cognitive impairment (CI) is an important consequence of epilepsy. The aim of the study was to assess cognitive performance in patients with epilepsy, using neuropsychological tests (NT) and event-related potentials (ERPs), with regard to demographic and clinical data. Methods: The study comprised [...] Read more.
Background: Cognitive impairment (CI) is an important consequence of epilepsy. The aim of the study was to assess cognitive performance in patients with epilepsy, using neuropsychological tests (NT) and event-related potentials (ERPs), with regard to demographic and clinical data. Methods: The study comprised 50 patients with epilepsy of unknown etiology and 46 healthy controls. Based on the NT results, the patients were divided into subgroups with/without CI. Parameters of P300 potential were compared between the patients and controls. P300 parameters and NT results were referred to demographics and clinical characteristics of epilepsy. Results: Based on the NT, 66% of patients were assigned as cognitively impaired. Median P300 latency was significantly (p < 0.0002) prolonged in the study group. Subgroups of patients with and without CI significantly (p < 0.034) differed in education level and vocational activity, duration of epilepsy, age at its onset and frequency of polytherapy. P300 parameters showed significant (p < 0.03) relationships with duration of epilepsy, type and frequency of seizures and polytherapy. Conclusions: Cognitive impairment and ERPs abnormalities occur in a majority of patients with epilepsy of unknown etiology. Characteristics of epilepsy and socioeconomic status are related to cognitive performance. ERPs may complement neuropsychological methods in the assessment of cognition in patients with epilepsy. Full article
(This article belongs to the Special Issue Epilepsy: Causes, Symptoms, Diagnosis, and Treatment)
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