Emerging Therapies for Multiple Myeloma

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1703

Special Issue Editor


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Guest Editor
Department of Hematology and Oncology, University of Rochester Medical Center, Rochester, NY 14642-0001, USA
Interests: multiple myeloma; other plasma cell disorders

Special Issue Information

Dear Colleagues,

Multiple myeloma (MM) is a complex hematological malignancy. The treatment of multiple myeloma has evolved rapidly in recent years with the emergence of many new drugs and new data from randomized trials. These research frontiers have brought new hope for the treatment of multiple myeloma.

This Special Issue focuses on the latest advances and trends in the treatment of multiple myeloma. We hope to contribute to a comprehensive understanding of multiple myeloma treatment by providing insight into the rationale, clinical trial results, and potential applications of emerging therapeutic approaches. The scope of this Special Issue covers a variety of emerging treatment methods, including but not limited to targeted therapy, immunotherapy, CAR-T cell therapy, new drugs, and personalized medicine.

We invite researchers in the field of multiple myeloma-related areas to submit their findings as original articles or reviews to this Special Issue.

Dr. Brea C. Lipe
Guest Editor

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Keywords

  • multiple myeloma
  • immunotherapy
  • targeted therapy
  • CAR-T cell therapy
  • new drugs
  • transplant

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Published Papers (1 paper)

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Research

12 pages, 755 KiB  
Article
Impact of Prior Selinexor Exposure on Outcomes of Chimeric Antigen Receptor T-Cell Therapy for Relapsed/Refractory Multiple Myeloma: An Exploratory Analysis
by Bruno Almeida Costa, Danai Dima, Tomer Mark, Norah Layla Sadek, Stephen Ijioma, David Ray, Utkarsh Goel, George Dranitsaris, Tianxiang Sheng, Erin Moshier, Tarek H. Mouhieddine, Jack Khouri and Adriana Rossi
J. Clin. Med. 2025, 14(4), 1316; https://doi.org/10.3390/jcm14041316 - 16 Feb 2025
Viewed by 1210
Abstract
Background/Objectives: Chimeric antigen receptor T-cell therapy (CAR-T) has become a key treatment option for relapsed/refractory multiple myeloma (RRMM), but factors impairing T-cell fitness may diminish efficacy. Our exploratory analysis aimed to evaluate the impact of prior treatment with a selinexor-containing regimen on [...] Read more.
Background/Objectives: Chimeric antigen receptor T-cell therapy (CAR-T) has become a key treatment option for relapsed/refractory multiple myeloma (RRMM), but factors impairing T-cell fitness may diminish efficacy. Our exploratory analysis aimed to evaluate the impact of prior treatment with a selinexor-containing regimen on CAR-T outcomes for RRMM patients. Methods: Data for this retrospective cohort study were sourced from electronic medical records at two US academic centers. Kaplan–Meier estimates assessed duration of response (DOR), progression-free survival (PFS), and overall survival (OS), reported as medians with interquartile ranges (IQRs). Cox proportional hazards regression analyzed factors potentially associated with PFS and OS, reported as hazard ratios (HRs) with 95% confidence intervals (CIs). Results: Among 45 patients exposed to selinexor before undergoing BCMA-directed CAR-T, median therapy line numbers for selinexor use and CAR-T were 7 and 9, respectively, with 24.4% receiving selinexor as part of bridging. At median follow-up of 68 months, median PFS and OS post CAR-T were 8.0 (IQR 3.1–39.5) and 35.9 (IQR 14.2–NR) months, respectively. Overall response rate to CAR-T was 89%, with a median DOR of 8.1 months (IQR 2.9–39.0). In our multivariable model, patients who received a selinexor-based regimen in the line of therapy preceding CAR-T showed a trend toward reduced risk of death (HR = 0.08; 95% CI 0.02–0.46) and/or disease progression (HR = 0.40; 95% CI 0.14–1.09). Conclusions: Prior selinexor exposure does not appear to compromise CAR-T outcomes in heavily pretreated RRMM, suggesting potential T-cell sparing. Our findings warrant larger, prospective studies to determine whether preemptive selinexor treatment can optimize CAR-T efficacy. Full article
(This article belongs to the Special Issue Emerging Therapies for Multiple Myeloma)
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