Special Issue "The Role of Heart and Brain in the Loss of Consciousness: Best Frenemies?"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 15 August 2023 | Viewed by 60

Special Issue Editors

Unit of Neurology, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
Interests: epilepsy surgery; neurophysiology in intensive care unit; status epilepticus
Prof. Dr. Roberto Michelucci
E-Mail Website
Guest Editor
Unit of Neurology, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
Interests: epilepsy; neurophysiology

Special Issue Information

Dear Colleagues,

Since ancient times, physicians have been fascinated by the complex and heterogeneous interaction between the heart and brain. The supremacy of one over the other was differently established during the epochs. The most frequent heart–brain pathology is the loss of consciousness which, with a lifetime prevalence of 50% in the general population, is one of the most common medical problems. Seizures, syncopes, and psychogenic non-epileptic seizures (PNES) account for about 90% of loss-of-consciousness cases. The limbic system is the common thread of many of these conditions, justifying situational syncope as well as focal epileptic seizures with arrhythmia. However, the constellation of different loss of consciousness mechanisms is much more varied, holding the greatest surprises, including syncope-induced seizures, arrhythmias that induce ictal-like symptoms, and arrhythmias or seizure-induced heart diseases. If this were not enough, recent studies on heart rate variability in epileptic patients have documented its relevance in predicting seizures.

In this Special Issue, we welcome the submission of original basic and clinical research, articles, and reviews aimed at elucidating the pathophysiological mechanisms underlying the brain–heart relationship and speeding up the diagnosis and management of these patients.

Dr. Elena Pasini
Prof. Dr. Roberto Michelucci
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  •  loss of consciousness
  •  epilepsy
  •  ictal arrhythmia
  •  ictal asystole
  •  heart rate variability

Published Papers

This special issue is now open for submission.
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