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Innovative Research for Personalized Prevention and Management of Heart Failure across the Cardiovascular Continuum

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 1198

Special Issue Editors


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Guest Editor
Cardiology Department, Bellvitge University Hospital, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
Interests: heart failure; health services and outcomes research; translational research; iron deficiency; eHealth; chronic cardiovascular conditions
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Cardiology Department, Bellvitge University Hospital, L’Hospitalet de Llobregat, 08907 Barcelona, Spain
Interests: heart failure; arrhythmia

Special Issue Information

Dear Colleagues,

Heart failure stands as a significant and escalating public health concern. It is currently a devastating syndrome with a very negative impact on mortality, morbidity, and health-related quality of life. Acknowledged as an international healthcare priority, the increasing prevalence of heart failure, coupled with rising medical resource use and expenditure, underscores the need for innovative approaches.

In addressing the urgent challenges posed by heart failure, our upcoming Special Issue endeavors to explore innovative research that redefines the landscape of cardiovascular care. From personalized medicine breakthroughs and multidisciplinary insights to the integration of technological advancements and the far-reaching impact on population health, this Special Issue will improve our understanding of and strategies for preventing and managing heart failure across the cardiovascular continuum.

Dr. Josep Comín-Colet
Dr. Cristina Enjuanes-Grau
Guest Editors

Manuscript Submission Information

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Keywords

  • chronic heart failure
  • cardiovascular comorbidities
  • personalized medicine
  • multidisciplinary management

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Published Papers (1 paper)

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Research

13 pages, 1337 KiB  
Article
No Obesity Paradox for Health-Related Quality of Life in Patients with Heart Failure and Reduced Ejection Fraction: Insights from the VIDA Multicenter Study
by Paula Cassadó-Valls, Cristina Enjuanes, Manuel Anguita, Francesc Formiga, Luis Almenar, María G. Crespo-Leiro, Luis Manzano, Javier Muñiz, José Chaves, Encarna Hidalgo, Raúl Ramos-Polo, Sergi Yun, Núria José-Bazán, Pedro Moliner and Josep Comín-Colet
J. Clin. Med. 2024, 13(24), 7558; https://doi.org/10.3390/jcm13247558 - 12 Dec 2024
Viewed by 776
Abstract
Background and Objectives: Previous studies showed that, paradoxically, obese patients with heart failure (HF) have better clinical outcomes compared to overweight, normal, or underweight patients. Scientific societies emphasize the importance of integrating quality of life (QoL) assessment in cardiovascular care. However, the association [...] Read more.
Background and Objectives: Previous studies showed that, paradoxically, obese patients with heart failure (HF) have better clinical outcomes compared to overweight, normal, or underweight patients. Scientific societies emphasize the importance of integrating quality of life (QoL) assessment in cardiovascular care. However, the association between QoL and weight remains understudied. Given the significant correlation between HF survival and QoL, it is essential to assess how obesity impacts patient-reported outcomes in this clinical setting. Methods: This cross-sectional multicenter study in 1028 HF patients with reduced ejection fraction (HFrEF) aims to evaluate the association between obesity and QoL, and whether the obesity paradox holds for HF patients regarding QoL. Specific and generic QoL questionnaires were administered alongside clinical parameters like body mass index (BMI) and body adiposity estimator (BAE). Results: Obese compared to non-obese reported worse QoL. In the adjusted linear regression models, neither BMI nor obesity were associated with QoL. Generalized additive models confirmed a strong non-parametric association between BMI, subdomain scores from Kansas City Cardiomyopathy Questionnaire (KCCQ) (OSS p = 0.004, CSS p = 0.006, TSS p = 0.02), and summary measurements of EQ-5D (EQ-5D index p = 0.003, visual analogue scale (VAS) p = 0.01). In contrast, BAE showed a statistically significant linear relation among QoL (OSS p ≤ 0.001, CSS p ≤ 0.001, TSS p ≤ 0.001) and EQ-5D summary measurements (EQ-5D index p ≤ 0.001, VAS p ≤ 0.001). Conclusions: Overall, obese patients have worse QoL; therefore, obesity cannot be considered a protective factor in terms of QoL in established HF. Full article
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