Next Article in Journal
Dissimilar Effects of Anagliptin and Sitagliptin on Lipoprotein Subclass in Standard or Strong Statin-Treated Patients with Type-2 Diabetes Mellitus: A Subanalysis of the REASON (Randomized Evaluation of Anagliptin versus Sitagliptin on Low-Density LipoproteiN Cholesterol in Diabetes) Trial
Next Article in Special Issue
Sensitivity of Viscoelastic Tests to Platelet Function
Previous Article in Journal
Why Uptake of Blended Internet-Based Interventions for Depression Is Challenging: A Qualitative Study on Therapists’ Perspectives
Previous Article in Special Issue
Rivaroxaban Effects Illustrate the Underestimated Importance of Activated Platelets in Thrombin Generation Assessed by Calibrated Automated Thrombography
Review

Clinical Applications, Pitfalls, and Uncertainties of Thrombin Generation in the Presence of Platelets

1
Clinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, 55131 Mainz, Germany
2
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, 6200 Maastricht, The Netherlands
3
Department of Internal Medicine, Laboratory of Clinical Thrombosis and Haemostasis, and Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, 6200 Maastricht, The Netherlands
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(1), 92; https://doi.org/10.3390/jcm9010092
Received: 2 December 2019 / Revised: 24 December 2019 / Accepted: 24 December 2019 / Published: 30 December 2019
Platelet-dependent thrombin generation is a helpful tool to assess ex vivo the interaction between platelets and plasma coagulation factors in the initiation, amplification, and inhibition of thrombin generation (TG). This review article discusses the most relevant available data on the clinical applications of fluorogenic TG, the most widely used TG assay, performed in the presence of platelets, i.e., in platelet-rich plasma. With respect to prothrombotic states, arterial hypertension and obesity were the most prominent cardiovascular conditions linked to increased platelet-dependent TG. In addition, platelet-associated hypercoagulability, assessed by the TG assay, has been shown in individuals with active cancer. In terms of bleeding, platelet-dependent TG has been applied to assess bleeding risk in individuals with hemophilia, von Willebrand disease, and Glanzmann thrombasthenia as well as in subjects with other congenital or acquired coagulation factor deficiencies. In addition to risk prediction, a role of the TG assay has been suggested in monitoring antiplatelet therapy in prothrombotic conditions and replacement therapy in bleeding diathesis. Finally, for the routine clinical use and as a biomarker of disease development and progression, better standardization and clinical validation of platelet-dependent TG are still needed. View Full-Text
Keywords: platelets; thrombin generation; cardiovascular risk factors; cardiovascular diseases; thrombosis; bleeding; hemophilia; von Willebrand disease platelets; thrombin generation; cardiovascular risk factors; cardiovascular diseases; thrombosis; bleeding; hemophilia; von Willebrand disease
Show Figures

Figure 1

MDPI and ACS Style

Panova-Noeva, M.; van der Meijden, P.E.J.; ten Cate, H. Clinical Applications, Pitfalls, and Uncertainties of Thrombin Generation in the Presence of Platelets. J. Clin. Med. 2020, 9, 92. https://doi.org/10.3390/jcm9010092

AMA Style

Panova-Noeva M, van der Meijden PEJ, ten Cate H. Clinical Applications, Pitfalls, and Uncertainties of Thrombin Generation in the Presence of Platelets. Journal of Clinical Medicine. 2020; 9(1):92. https://doi.org/10.3390/jcm9010092

Chicago/Turabian Style

Panova-Noeva, Marina, Paola E.J. van der Meijden, and Hugo ten Cate. 2020. "Clinical Applications, Pitfalls, and Uncertainties of Thrombin Generation in the Presence of Platelets" Journal of Clinical Medicine 9, no. 1: 92. https://doi.org/10.3390/jcm9010092

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop