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Indocyanine Green Fluorescence in Gynecology

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 330

Special Issue Editors


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Guest Editor
Department of Gynecological Oncology, AZ Sint-Jan Hospital Bruges, Ruddershove 10, 8000 Bruges, Belgium
Interests: gynecological cancer; endometriosis; minimally invasive surgery; robotic surgery

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Guest Editor
Gynaecological Oncology Department Metaxa Cancer Hospital, 18537 Piraeus, Greece
Interests: gynaecological oncology; robotic gynaecology; laparoscopic gynaecology; cancer; endometriosis
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Special Issue Information

Dear Colleagues,

Indocyanine green (ICG) is a water-soluble fluorescent dye that was approved by the FDA for biomedical applications in 1956. Initially, the fluorescent properties of ICG in the near-infrared (NIR) spectrum were utilized to assess cardiocirculatory and hepatic functions. Subsequently, it found applications in ophthalmic angiography and neurosurgery as an angiographic tool. Due to its superior tissue penetration in the NIR spectrum compared to other FDA-approved fluorophores, ICG has been employed across a broad range of medical fields. In gynecology, ICG has been adopted in several subdisciplines, including sentinel lymph node detection in cervical and endometrial cancer during minimally invasive surgery, visualization of vascularity in peritoneal carcinomatosis associated with ovarian cancer, highlighting neovascularization in peritoneal endometriosis during surgery, and visualization of the bladder and ureters during deep infiltrating endometriosis surgery. This Special Issue aims to highlight and examine the current applications of ICG in various gynecological pathologies.

Dr. Philippe Van Trappen
Dr. Christos R. Iavazzo
Guest Editors

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Keywords

  • cancer
  • endometriosis
  • indocyanine green
  • minimally invasive
  • robotic

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Published Papers (1 paper)

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Research

11 pages, 414 KiB  
Article
Route of Surgery for Sentinel Node Biopsy in Endometrial Cancer: Laparoscopy Versus Robotics
by Angela Fierro, Isabel Flores, Irene Pellicer, Maria Alonso-Espias, Virginia Garcia-Pineda, Ignacio Zapardiel and Myriam Gracia
J. Clin. Med. 2025, 14(12), 4013; https://doi.org/10.3390/jcm14124013 - 6 Jun 2025
Abstract
Background/Objective: Sentinel lymph node (SLN) mapping is an accepted technique for the nodal staging of early-stage endometrial cancer. It is carried out commonly by minimally invasive approach, either by laparoscopy or robotics-assisted surgery. The primary aim of this study was to compare [...] Read more.
Background/Objective: Sentinel lymph node (SLN) mapping is an accepted technique for the nodal staging of early-stage endometrial cancer. It is carried out commonly by minimally invasive approach, either by laparoscopy or robotics-assisted surgery. The primary aim of this study was to compare the detection rate of SLN mapping between laparoscopic and robotic surgery. Methods: A retrospective observational study including patients operated on from February 2024 to March 2025, diagnosed with endometrial cancer who underwent hysterectomy, bilateral salpingo-oophorectomy and SLN mapping. Among a total of 60 patients, 38 (63.3%) underwent laparoscopic surgery and 22 (36.7%) robotic surgery. We compared SLN detection rate and perioperative outcomes between the two routes of approach. Results: No significant differences were observed in the overall and bilateral SLN detection rate between laparoscopic and robotic surgery (97.3% and 84.2% vs. 95.5% and 91%, respectively). Significant differences were observed in operative time, with a median of 125 vs. 110 min (p = 0.004), and in hospital stay, with a median of 3 vs. 2 days (p = 0.002), with both being shorter in the robotic surgery group. No differences were observed in terms of number of SLN detected, percentage of positive nodes, intra or postoperative complications rate, or percentage of conversion to laparotomy. Conclusions: No differences were found in SLN detection rates between laparoscopic and robotic surgery. However, robotic surgery demonstrated advantages in terms of reduced operative time and shorter hospital stay. Full article
(This article belongs to the Special Issue Indocyanine Green Fluorescence in Gynecology)
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