New Insights into the Role of Mitochondrial Dysfunction in Diseases

Dear Colleagues,

Mitochondria are essential organelles in all eukaryotic cells. They provide ATP via the oxidative phosphorylation system, thus functioning as the fulcrum of metabolic pathways, primary sources of reactive oxygen species (ROS), buffers of intracellular calcium, and regulators of apoptosis as well as of signal transduction.

To ensure maximal mitochondrial function, mitochondrial quality control systems protect mitochondria from damage at the protein and DNA level by activating antioxidant systems, mitochondrial proteases, and mtDNA repair machinery. Moreover, at the organelle level, damaged mitochondria are removed through mitophagy and functional mitochondria are maintained through enhancing mitochondrial biogenesis and modulating mitochondrial dynamics.

A flaw in these systems may lead to mitochondrial dysfunctions such as mtDNA alterations (mutations and altered mtDNA content), mitochondrial respiratory chain activity defects, and altered mitochondrial morphology.

The aim of this Special Issue is to collect novel findings in the field of mitochondrial dysfunctions in diseases including but not limited to cancer, neurodegenerative disorders, and diabetes.

We cordially invite scientists involved in base research as well as in translational studies to submit their original researches or review manuscripts to this Special Issue.

Dr. Antonella Cormio
Dr. Clara Musicco
Guest Editors

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