Nervous System and COVID-19

Dear Colleagues, 

Since the beginning of 2020, healthcare workers around the world have been facing challenges linked to the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a new virus which first emerged in Wuhan, China. COVID-19 infection presents complex clinical features, far beyond the first described pneumonia cases in Wuhan, with a frequent involvement of the peripheral and central nervous system. Indeed, a broad spectrum of neurological consequences has been associated with COVID-19 infection. Acute neurological symptoms and manifestations can include fatigue, headache, myalgia, confusion, stroke, seizure, insomnia, anosmia, and ageusia, while subacute neurological conditions include encephalitis, Guillain–Barre syndrome, polyneuritis, myelitis, generalized myoclonus, and opsoclonus. These COVID-19 neurological manifestations have been linked to several pathophysiological mechanisms. Although extensively investigated, many issues of neurological involvement in COVID-19 infection need to be clarified, including the detailed clinical course of patients with neuro-COVID-19, the impact of pre-existing neurological diseases on infection, the long-term consequences of COVID-19 infection on the nervous system, and its possible role as a trigger for the development of neurodegenerative diseases.  

Thus, this Special Issue focuses on generating valuable scientific knowledge on the neurological consequences of COVID-19 and its mechanisms and associated clinical, biological, and neuroimaging issues. 

We sincerely look forward to receiving your contributions.

You may choose our Joint Special Issue in Biomolecules.

Dr. Maria Luisa Zedde
Dr. Francesco Cavallieri
Guest Editors

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• COVID-19
• neuro-COVID
• nervous system
• coronavirus