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Diabetic Nephropathy: Pathogenesis, Prevention and Treatment
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Diabetic Nephropathy: Pathogenesis, Prevention and Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 747

Special Issue Editor

Dr. Atsushi Fukatsu

E-Mail Website
Guest Editor
Fukatsu Medical Clinic, Anjo 446-0026, Japan
Interests: mechanisms involved in the progression of renal diseases

Special Issue Information

Dear Colleagues,

The pathogenesis of diabetic nephropathy is complex, involving multiple factors such as hyperglycemia, oxidative stress, inflammation, and genetic susceptibility. The articles in the Special Issue examine these factors in detail and discuss potential targets for intervention.

Prevention is a crucial aspect of managing diabetic nephropathy. Lifestyle modifications such as weight loss, exercise, and a healthy diet can help prevent the development and progression of the condition. The Special Issue also explores pharmacological interventions and the role of biomarkers in predicting the risk of diabetic nephropathy.

Treatment of diabetic nephropathy includes blood glucose and blood pressure control, as well as the use of medications such as angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and sodium-glucose co-transporter 2 inhibitors. The articles in the Special Issue discuss the latest advances in these treatments and the potential of novel therapies.

Overall, the Special Issue provides a comprehensive overview of diabetic nephropathy, highlighting the importance of understanding its pathogenesis, preventing its development, and effectively managing the condition. 

Dr. Atsushi Fukatsu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetic nephropathy
  • pathogenesis
  • prevention
  • treatment
  • renal diseases

Published Papers (1 paper)

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Research

10 pages, 2521 KiB  
Article
The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Increased Glomerular Production or Permeability in Diabetes Mellitus?
by Shengyuan Xu, Anders Larsson, Lars Lind, Cecilia Lindskog, Johan Ärnlöv and Per Venge
J. Clin. Med. 2024, 13(9), 2629; https://doi.org/10.3390/jcm13092629 - 30 Apr 2024
Viewed by 484
Abstract
Background: A previous report showed that the urine output of HPLBII-P in patients with diabetes mellitus and SARS-CoV-2 infection was increased as a sign of glomerular dysfunction. The aim of this report was to investigate the relation of the urine output of HPLBII-P [...] Read more.
Background: A previous report showed that the urine output of HPLBII-P in patients with diabetes mellitus and SARS-CoV-2 infection was increased as a sign of glomerular dysfunction. The aim of this report was to investigate the relation of the urine output of HPLBII-P to diabetes mellitus in two large community-based elderly populations, i.e., the ULSAM and PIVUS cohorts. Methods: HPLBII-P was measured by an ELISA in the urine of a community-based cohort of 839 men (ULSAM) collected at 77 years of age and in the urine of a community-based cohort of 75-year-old men, n = 387, and women, n = 401 (PIVUS). KIM-1, NGAL, and albumin were measured in urine and cathepsin S and cystatin C in serum. Results: HPLBII-P was significantly raised among males with diabetes in the ULSAM (p < 0.0001) and PIVUS cohorts (p ≤ 0.02), but not in the female cohort of PIVUS. In the female subpopulation of insulin-treated diabetes, HPLBII-P was raised (p = 0.02) as compared to women treated with oral antidiabetics only. In the ULSAM cohort, HPLBII-P was correlated to NGAL, KIM-1, and albumin in urine both in non-DM (all three biomarkers; p < 0.0001) and in DM (NGAL; p = 0.002, KIM-1; p = 0.02 and albumin; p = 0.01). Plasma glucose and HbA1c in blood showed correlations to U-HPLBII-P (r = 0.58, p < 0.001 and r = 0.42, p = 0.004, respectively). U-HPLBII-P and cathepsin S were correlated in the ULSAM group (r = 0.50, p < 0.001). No correlations were observed between U-HPLBII-P and serum creatinine or cystatin C. Conclusions: The urine measurement of HPLBII-P has the potential to become a novel and useful biomarker in the monitoring of glomerular activity in diabetes mellitus. Full article
(This article belongs to the Special Issue Diabetic Nephropathy: Pathogenesis, Prevention and Treatment)
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