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Clinical Progress of Mastectomy and Breast Reconstruction Surgery
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Clinical Progress of Mastectomy and Breast Reconstruction Surgery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine".

Deadline for manuscript submissions: 28 August 2025 | Viewed by 599

Special Issue Editors

Dr. Antoine L. Carre

E-Mail Website
Guest Editor
Division of Plastic Surgery, City of Hope National Medical Center, Duarte, CA, USA
Interests: autologous breast reconstruction (DIEP, PAP, and LAP flaps); alloplastic reconstruction; nipple areola complex preservation in large mastectomy; improved aesthetic of breast reconstruction; restore function after breast reconstruction
Dr. Mouchammed Agko

E-Mail Website
Guest Editor
Section of Plastic Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA
Interests: microsurgery; reconstructive surgery; rhinoplasty; lymphedema

Special Issue Information

Dear Colleagues,

The progress in the techniques utilized in breast reconstruction has been remarkable. Various types of breast autologous or alloplastic reconstruction (direct to implant pre-pectoral breast reconstruction, robotic DIEP flap, PAP flap, LAP flap, reinnervation of all of these techniques, etc.), which were previously performed in a few centers, have become more routine and common with the spread of microsurgical training and fellowship. Moreover, the new development of surgical robots, such the da Vinci SP robotic system and the Symani surgical system, has opened up further possibilities with predictable results. On the other hand, mastectomy techniques and incision placement have also made significant progress. The use of PlasmaBlade during mastectomy has expanded the predictability and feasibility of target nipple areola complex reinnervation, and new technology with nerve allografts and nerve coduit is being developed to increase the success rate of these procedures. In particular, the advancen techniques that allow for the preservation of the nipple areola complex in large ptotic breasts while simutaneously performing a direct implant reconstruction on the day of the mastectomy. In this Special Issue, we welcome authors to submit papers on the clinical advances of alloplatic and autologous breast reconstruction and all the nuances that are applied to these two approaches to further enhance function and aesthetics, as well as new advances in mastectomy techniques, including robotic mastectomies.

Dr. Antoine L. Carre
Dr. Mouchammed Agko
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • autologous breast reconstruction
  • reinnervation
  • mastectomy
  • robotic DIEP (deep inferior epigastric perforator) flap
  • rib-sparing DIEP flap
  • neurotization of DIEP flap
  • nipple-sparing neurotization
  • nipple-sparing mastectomy of large breasts
  • hematoma after mastectomy
  • robotic mastectomy
  • pre-pectoral alloplastic reconstruction

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Published Papers (1 paper)

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15 pages, 663 KiB  
Systematic Review
Salvage of the Mastectomy Pocket in Infected Implant-Based Breast Reconstruction Using Negative-Pressure Wound Therapy with Instillation and Dwell: A Systematic Review and Meta-Analysis
by Laura De Pellegrin, Isabel Zucal, Giorgio Treglia, Corrado Parodi, Riccardo Schweizer, Marco De Monti and Yves Harder
J. Clin. Med. 2025, 14(8), 2730; https://doi.org/10.3390/jcm14082730 - 16 Apr 2025
Viewed by 312
Abstract
Background: Breast cancer, irrespective of gender, stands as the most prevalent cancer globally, with an annual estimate of 2.3 million new cases. Surgical intervention, including therapeutic mastectomy (excluding prophylactic procedures), is performed on approximately 28% of patients, necessitating subsequent breast reconstruction. Although implant-based [...] Read more.
Background: Breast cancer, irrespective of gender, stands as the most prevalent cancer globally, with an annual estimate of 2.3 million new cases. Surgical intervention, including therapeutic mastectomy (excluding prophylactic procedures), is performed on approximately 28% of patients, necessitating subsequent breast reconstruction. Although implant-based breast reconstruction (IBBR) is frequently employed due to its relative ease compared to autologous methods, it presents a notable risk for complications at mid-term such as peri-prosthetic infections. These complications can lead to implant loss and the eventual compromise of the mastectomy pocket. To address these complications, negative pressure wound therapy with instillation and dwell (NPWTi-d) emerges as a promising rescue intervention, known for its capacity to significantly reduce bacterial load and potentially salvage compromised soft tissues. However, the evidence supporting its effectiveness in infected pockets after mastectomy is currently insufficient. This study aims at investigating the efficacy of NPWTi-d in the management of peri-prosthetic mastectomy pocket infection. Methods: A thorough literature search has been concluded through PubMed, Web of Science, and Cochrane databases up until 18th March 2025 on evaluating NPWTi-d’s ability to manage peri-prosthetic infections and preserve mastectomy pockets for subsequent reconstruction. Furthermore, a meta-analysis on the salvage rate of the mastectomy pocket was carried out, while for other outcomes, a descriptive analysis was applied. Results: Nine studies (n = 230 patients) were included, investigating whether the us NPWTi-d was successful in treating peri-prosthetic infection and preserving the mastectomy pocket for subsequent reconstruction by expander or implant. The pooled salvage rate of the implant-based BR due to the use of NPWTi-d was 86.1% (95%CI: 80.6–91.6%). Preservation of the skin envelope avoided secondary reconstruction after a defined time interval, reducing number and complexity of surgeries and related costs. Conclusions: This innovative surgical approach should be considered in selected cases of infected implants after breast reconstruction in breast cancer centers. However, the actual low level of evidence is based on case series, and it is not possible to define generally accepted recommendations for the use of NPWTi-d to save the mastectomy pocket. Full article
(This article belongs to the Special Issue Clinical Progress of Mastectomy and Breast Reconstruction Surgery)
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