Recent Advances in Colorectal Carcinogenesis and Prevention
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: closed (20 August 2021) | Viewed by 15223
Special Issue Editors
Interests: surgery; surgical oncology; hereditary cancer; colorectal cancer
Special Issue Information
Dear Colleagues,
Recent advances in the research of colorectal carcinogenesis have revealed heterogeneity and individual variation in clinical behavior and therapeutic responses. Molecular characterization into hyper- and non-hypermutated tumors and further subclassification into immune, canonical, metabolic, and mesenchymal type of neoplasms with a wide variation of clinical and prognostic features challenges the present frameworks of care, which are geared toward controlling homogeneous diseases. The methods to measure host immune response in eliminating tumor growth and estimating the tumor’s ability to escape the cytotoxic mechanisms of the body have recently opened new therapeutic avenues and created new prognostic biomarkers. It is quite likely that carcinogenetic circumstances vary in different parts of the large bowel. Proximal colon is derived from the midgut and distal part from the hindgut, which seems to modify the molecular genetic landscape of the developing tumors. Additionally, the activity and distribution of the microbiome correlate to the location. Blood-based biomarkers have taken significant leaps forward, providing tools for early detection and monitoring minimal residual disease after therapy.
The primary prevention of colorectal cancer in risk groups has recently achieved important steps toward clinical practice. The long-term results of aspirin chemoprevention have recently been published, and vaccine-based reinforcing of the immune system is already at the stage of preliminary clinical tests in Lynch syndrome.
In this Special Issue, JCM will publish a representative collection of manuscripts (reviews and original studies) comprising the aforementioned aspects in colorectal carcinogenesis.
Dr. Toni T. Seppälä
Prof. Dr. Jukka-Pekka Mecklin
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer biomarkers
- tumor microenvironment
- cell-free DNA
- gut microbiome
- carcinogenesis
- cancer prevention
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.