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Clinical Advances in Hepatobiliary Surgery: Diagnosis, Prognosis, Management & Surgery...
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Clinical Advances in Hepatobiliary Surgery: Diagnosis, Prognosis, Management & Surgery for Colorectal Liver Metastases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 2871

Special Issue Editors

Dr. Alexandros Giakoustidis

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Guest Editor
Aristotle University Surgery Department, Papageorgiou Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: liver; pancreas; biliary; laparoscopic surgery; gastrointestinal; prognostic ratios
Prof. Dr. Vasileios N. Papadopoulos

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Guest Editor
Director of Aristotle University Surgery Department, Papageorgiou Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: gastrointestinal; breast; biliary
Special Issues, Collections and Topics in MDPI journals
Dr. Dimitris E. Giakoustidis

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Guest Editor
Aristotle University Surgery Department, Papageorgiou Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: liver; pancreas; biliary; laparoscopic surgery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Guido Torzilli

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Guest Editor
Director of Department of Surgery, Division of Hepatobiliary Surgery & General Surgery, Humanitas Research Hospital, 20089 Rozzano, Italy
Interests: liver; laparoscopic surgery; intraoperative US of liver
Special Issues, Collections and Topics in MDPI journals
Dr. Matteo Donadon

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Guest Editor
Director of Surgical Oncology Program, University of Piemonte Orientale, University Maggiore Hospital, 28100 Novara, NO, Italy
Interests: liver; laparoscopic surgery; intraoperative US of liver
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue presents a comprehensive overview of the latest advancements in the field of hepatobiliary surgery, with a particular focus on the diagnosis, prognosis, management and surgical treatment of colorectal liver metastases. The issue brings together cutting-edge research, clinical insights and expert opinions from renowned specialists in the field, adding to the field with great depth and enormous clinical impact.

The Special Issue covers a wide range of topics, including innovative diagnostic techniques such as molecular imaging and liquid biopsies, prognostic factors and predictive models for colorectal liver metastases, minimally invasive surgical techniques and the role of multidisciplinary care in optimizing patient outcomes. We call for papers relating to these topics, in an effort to further stimulate the evaluation of current approaches and search for ways to move forward.

Dr. Alexandros Giakoustidis
Prof. Dr. Vasileios N. Papadopoulos
Dr. Dimitris E. Giakoustidis
Prof. Dr. Guido Torzilli
Dr. Matteo Donadon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver metastases
  • colorectal cancer
  • liver surgery
  • laparoscopic surgery
  • robotic surgery
  • pancreas

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

14 pages, 2308 KiB  
Article
Impact of Positive Lymph Nodes after Systematic Perihilar Lymphadenectomy in Colorectal Liver Metastases
by Gabriel F. Hess, Noa L. E. Aegerter, Jasmin Zeindler, Jürg Vosbeck, Kerstin J. Neuschütz, Philip C. Müller, Simone Muenst, Silvio Däster, Martin Bolli, Otto Kollmar and Savas D. Soysal
J. Clin. Med. 2024, 13(17), 5301; https://doi.org/10.3390/jcm13175301 - 6 Sep 2024
Abstract
Background: 25 to 50% of patients suffering from colorectal cancer develop liver metastases. The incidence of regional lymph node (LN) metastases within the liver is up to 14%. The need for perihilar lymph node dissection (LND) is still a controversial topic in patients [...] Read more.
Background: 25 to 50% of patients suffering from colorectal cancer develop liver metastases. The incidence of regional lymph node (LN) metastases within the liver is up to 14%. The need for perihilar lymph node dissection (LND) is still a controversial topic in patients with colorectal liver metastases (CRLM). This study investigates the role of perihilar LND in patients with CRLM. Methods: For this retrospective study, patients undergoing surgery for CRLM at the University Hospital Basel between May 2009 and December 2021 were included. In patients with perihilar LND, LN were stained for CK22 and examined for single tumour cells (<0.2 mm), micro- (0.2–2 mm), and macro-metastases (>2 mm). Results: 112 patients undergoing surgery for CRLM were included. 54 patients underwent LND, 58/112 underwent liver resection only (LR). 3/54 (5.6%) showed perihilar LN metastases in preoperative imaging, and in 10/54 (18.5%), micro-metastases could be proven after CK22 staining. Overall complications were similar in both groups (LND: 46, 85.2%; LR: 48, 79.3%; p = 0.800). The rate of major complications was higher in the LND group (LND: 22, 40.7%; LR: 18, 31%, p = 0.002). Median recurrence-free survival (RFS) (LND: 10 months; LR: 15 months, p = 0.076) and overall survival (OS) were similar (LND: 49 months; LR: 60 months, p = 0.959). Conclusion: Preoperative imaging is not sensitive enough to detect perihilar LN metastases. Perihilar LND enables precise tumour staging by detecting more lymph node metastases, especially through CK22 staining. However, perihilar LND does not influence oncologic outcomes in patients with CRLM. Full article
(This article belongs to the Special Issue Clinical Advances in Hepatobiliary Surgery: Diagnosis, Prognosis, Management & Surgery for Colorectal Liver Metastases)
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19 pages, 290755 KiB  
Article
Gelatin-Based Liver Phantoms for Training Purposes: A Cookbook Approach
by Radu Claudiu Elisei, Florin Graur, Amir Szold, Andreas Melzer, Sever Cãlin Moldovan, Mihai Motrescu, Emil Moiş, Cãlin Popa, Doina Pîsla, Cãlin Vaida, Tiberiu Tudor, Adrian Coţe and Nadim Al-Hajjar
J. Clin. Med. 2024, 13(12), 3440; https://doi.org/10.3390/jcm13123440 - 12 Jun 2024
Cited by 1 | Viewed by 727
Abstract
Background: Patients with liver pathology benefit from image-guided interventions. Training for interventional procedures is recommended to be performed on liver phantoms until a basic proficiency is reached. In the last 40 years, several attempts have been made to develop materials to mimic [...] Read more.
Background: Patients with liver pathology benefit from image-guided interventions. Training for interventional procedures is recommended to be performed on liver phantoms until a basic proficiency is reached. In the last 40 years, several attempts have been made to develop materials to mimic the imaging characteristics of the human liver in order to create liver phantoms. There is still a lack of accessible, reproducible and cost-effective soft liver phantoms for image-guided procedure training. Methods: Starting from a CT-scan DICOM file, we created a 3D-printed liver mold using InVesalius (Centro de Tecnologia da informação Renato Archer CTI, InVesalius 3 open-source software, Campinas, Brazil) for segmentation, Autodesk Fusion 360 with Netfabb (Autodesk software company, Fusion 360 2.0.19426 with Autodesk Netfabb Premium 2023.0 64-Bit Edition, San Francisco, CA, USA) for 3D modeling and Stratasys Fortus 380 mc 3D printer (Stratasys 3D printing company, Fortus 380 mc 3D printer, Minneapolis, MN, USA). Using the 3D-printed mold, we created 14 gelatin-based liver phantoms with 14 different recipes, using water, cast sugar and dehydrated gelatin, 32% fat bovine milk cream with intravenous lipid solution and technical alcohol in different amounts. We tested all these phantoms as well as ex vivo pig liver and human normal, fatty and cirrhotic liver by measuring the elasticity, shear wave speed, ultrasound attenuation, CT-scan density, MRI signal intensity and fracture force. We assessed the results of the testing performed, as well as the optical appearance on ultrasound, CT and MRI, in order to find the best recipe for gelatin-based phantoms for image-guided procedure training. Results: After the assessment of all phantom recipes, we selected as the best recipe for transparent phantoms one with 14 g of gelatin/100 mL water and for opaque phantom, the recipes with 25% cream. Conclusions: These liver gelatin-based phantom recipes are an inexpensive, reproducible and accessible alternative for training in image-guided and diagnostic procedures and will meet most requirements for valuable training. Full article
(This article belongs to the Special Issue Clinical Advances in Hepatobiliary Surgery: Diagnosis, Prognosis, Management & Surgery for Colorectal Liver Metastases)
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