Clinical Management of Multiple Sclerosis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 1020

Special Issue Editors


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Guest Editor
2nd Department of Neurology, Attikon University Hospital, 124 62 Athens, Greece
Interests: neurological diseases; multiple sclerosis; stroke; ischemic stroke

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Guest Editor
Second Department of Neurology, “Attikon” University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece
Interests: myasthenia gravis; multiple sclerosis; myelin oligodendrocyte glycoprotein antibody disease; myelooptic neuropathy

Special Issue Information

Dear Colleagues,

Recent advances in therapeutic interventions in multiple sclerosis have significantly enhanced disease management and the quality of life for patients. Over the past decade, research has delved into the prevalence and impact of comorbid conditions on disease progression, as well as on the overall welfare of patients with multiple sclerosis. Future perspectives entail the systematic documentation of comorbidities in this population, the exploration of the potential drug interactions with these comorbid conditions, and subsequently the relationship between the presence of comorbid conditions and disability progression. This Special Issue of the Journal of Clinical Medicine welcomes commentaries, original research and reviews focusing on the advances in research, diagnosis monitoring and treatment of multiple sclerosis and other demyelinating disorders. This Special Issue aims to enrich the current literature on the advances in phenotyping people with demyelinating disorders and comorbid conditions, personalised treatment strategies, and the systematic recording of these conditions.

Prof. Dr. Sotirios Giannopoulos
Dr. John S. Tzartos
Guest Editors

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Keywords

  • multiple sclerosis
  • comorbidities
  • quality of life
  • disease modifying treatments
  • demyelination disorders

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Published Papers (1 paper)

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Research

11 pages, 500 KiB  
Article
Evaluating Vaporized Cannabinoid Therapy in Multiple Sclerosis: Findings from a Prospective Single-Center Clinical Study
by Konstantina Stavrogianni, Dimitrios K. Kitsos, Vasileios Giannopapas, Vassiliki Smyrni, Athanasios K. Chasiotis, Alexandra Akrivaki, Evangelia-Makrina Dimitriadou, Christina Zompola, John S. Tzartos, Georgios Tsivgoulis and Sotirios Giannopoulos
J. Clin. Med. 2025, 14(6), 2121; https://doi.org/10.3390/jcm14062121 - 20 Mar 2025
Viewed by 835
Abstract
Introduction: Multiple Sclerosis (MS) is associated with a wide range of debilitating symptoms, and conventional therapies often fail to adequately address the disease’s multifaceted challenges. Cannabidiol (CBD) 13.0% + Delta9-tetrahydrocannabinol (THC) 9.0% (CBD13/THC9), a vaporized cannabis-based medicinal product, presents a novel therapeutic option [...] Read more.
Introduction: Multiple Sclerosis (MS) is associated with a wide range of debilitating symptoms, and conventional therapies often fail to adequately address the disease’s multifaceted challenges. Cannabidiol (CBD) 13.0% + Delta9-tetrahydrocannabinol (THC) 9.0% (CBD13/THC9), a vaporized cannabis-based medicinal product, presents a novel therapeutic option for managing MS symptoms. Methods: This single-center longitudinal study followed 69 MS patients over a six-month period. Participants were assessed at treatment initiation and at three- and six-month intervals. Key measures included muscle spasticity, urine bladder dysfunction, and the evaluation of disability progression rate. The evaluation included the Modified Ashworth Scale (MAS), the Post Void Residual (PVR) volume, and the Expanded Disability Status Scale (EDSS). Results: Significant improvement was observed across all outcome assessments. The EDSS score was decreased over time (p = 0.009), indicating a slight reduction in disability progression rate, while MAS scores showed substantial improvement in muscle spasticity (p < 0.001). Urine bladder function improved significantly, with PVR volume showing notable improvement between baseline and the six-month assessment (p < 0.001). Correlation analyses revealed that a gradual increase in vaporized CBD13/THC9 dose was correlated with slightly lower EDSS scores, while the adverse effects were negatively associated with the frequency of cannabinoid use. Finally, patients who were smokers used CBD13/THC9 more frequently. Conclusions: The vaporized CBD13/THC9 formulation demonstrated notable efficacy in slightly improving disability progression rate via reduction in muscle spasticity and urine bladder dysfunction in MS patients. This highlights its addon therapeutic value during rehabilitation in MS patients with debilitating disability symptoms. Full article
(This article belongs to the Special Issue Clinical Management of Multiple Sclerosis)
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