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Advances in the Management of Chronic Cough and Severe Asthma

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 2728

Special Issue Editor


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Guest Editor
1. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
2. Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), 28029 Madrid, Spain
3. Pulmonology Department, Hospital Clínic, Universitat de Barcelona, 08036 Barcelona, Spain
Interests: asthma; chronic cough; biomarkers; exacerbations; biologics; precision medicine; airway inflammation; pediatric asthma;

Special Issue Information

Dear Colleagues,

Cough and asthma remain leading causes of respiratory consultations worldwide, with substantial impact on quality of life and healthcare utilization. This Special Issue will highlight advances that enable more precise, effective, and timely management across ages and phenotypes. We welcome state-of-the-art reviews and original research on diagnostic pathways for chronic cough, endotyping and biomarkers in asthma (including type-2 and non-type-2 inflammation), imaging and lung function tools, and multimorbidity (e.g., rhinitis, CRSwNP, GERD). We also encourage submissions on severe asthma, exacerbation prevention, pediatric considerations, and implementation science to bridge guidelines and real-world practice. Our aim is to provide clinicians and researchers with practical, high-quality evidence to improve outcomes for people living with cough and asthma.

Dr. Ebymar Arismendi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • asthma
  • chronic cough
  • biomarkers
  • exacerbations
  • biologics
  • precision medicine
  • airway inflammation
  • pediatric asthma

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Published Papers (2 papers)

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Research

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13 pages, 787 KB  
Article
Peak Inspiratory Flow Capability for Simulated Dry Powder Inhaler Resistances in Asthma Patients Prescribed Pressurized Metered-Dose Inhalers with Valved Holding Chambers: The USE-DPI Study
by Lara Bravo Quiroga, José Miguel González Moro, Francisco Javier Álvarez-Gutiérrez, Krasimira Baynova, Mariam De La Poza Abad and José Luis Izquierdo Alonso
J. Clin. Med. 2026, 15(8), 3131; https://doi.org/10.3390/jcm15083131 - 20 Apr 2026
Viewed by 277
Abstract
Background: Inhaled therapy is the mainstay of asthma management, yet many patients are prescribed pressurized metered-dose inhalers (pMDIs) with valved holding chambers (VHCs) based on a presumed low inspiratory capacity, often without objective measurement. The USE-DPI study aimed to determine how many [...] Read more.
Background: Inhaled therapy is the mainstay of asthma management, yet many patients are prescribed pressurized metered-dose inhalers (pMDIs) with valved holding chambers (VHCs) based on a presumed low inspiratory capacity, often without objective measurement. The USE-DPI study aimed to determine how many of these patients can generate sufficient peak inspiratory flow (PIF) to use a dry powder inhaler (DPI). Methods: This multicenter, observational, cross-sectional study included 346 patients with asthma treated with pMDI and VHC. PIF was measured using the In-Check Dial at two resistance settings (R2 and R4). The primary outcome was the proportion of patients achieving PIF ≥ 30 L/min. Results: Almost all patients reached the 30 L/min threshold (99.4% at R2 and 98.7% at R4). Using a higher threshold of 60 L/min (R2), 76.1% met this criterion. Lower PIF (<60 L/min) was associated with older age, reduced lung function (FEV1 ≤ 80% predicted), and poorer asthma control. No significant variables were associated with failure to reach 30 L/min. Conclusions: Most patients using pMDI with VHC can generate sufficient inspiratory flow for medium- to high-resistance DPIs. Objective PIF assessment may help guide inhaler selection, although its clinical impact requires further study. Full article
(This article belongs to the Special Issue Advances in the Management of Chronic Cough and Severe Asthma)
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Review

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17 pages, 1235 KB  
Review
Severe Asthma Exacerbations: From Risk Factors to Precision Management Strategies
by Marina Paredes, Jeisson Osorio, Alberto García de la Fuente, Elena Rodríguez, César Picado, Iñigo Ojanguren and Ebymar Arismendi
J. Clin. Med. 2026, 15(2), 857; https://doi.org/10.3390/jcm15020857 - 21 Jan 2026
Cited by 1 | Viewed by 2212
Abstract
Background: Severe asthma exacerbations (SAEs) significantly contribute to asthma-related morbidity, mortality, and healthcare burden. Despite therapeutic advances, a subset of patients remains exacerbation-prone. This review aims to summarize current evidence on risk factors, phenotypes, and biomarkers associated with SAEs, and explore personalized [...] Read more.
Background: Severe asthma exacerbations (SAEs) significantly contribute to asthma-related morbidity, mortality, and healthcare burden. Despite therapeutic advances, a subset of patients remains exacerbation-prone. This review aims to summarize current evidence on risk factors, phenotypes, and biomarkers associated with SAEs, and explore personalized strategies for their acute management. Methods: We conducted a comprehensive literature review focusing on clinical, inflammatory, and environmental drivers of SAE. Special attention was given to Type 2 (T2) biomarkers—blood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO)—as tools for phenotyping and treatment guidance. Emerging evidence on the use of biologics during exacerbations was also analyzed. Results: SAEs are heterogeneous in etiology and inflammatory profile. Respiratory infections, allergen exposure, obesity, and comorbidities increase exacerbation risk. T2-high SAEs respond well to corticosteroids and biologics, whereas T2-low SAEs show limited treatment benefit. BEC and FeNO reliably predict exacerbation risk and corticosteroid responsiveness. Recent case reports suggest potential roles for anti-IL-5 and anti-thymic stromal lymphopoietin (TSLP) biologics in acute care. Conclusions: Biomarker-guided management of SAEs may enhance therapeutic precision and avoid overtreatment. Integrating phenotypic (observable characteristics) and endotypic (biological markers) assessment into acute care could improve patient outcomes and optimize resource use. Prospective trials are needed to confirm these approaches. Full article
(This article belongs to the Special Issue Advances in the Management of Chronic Cough and Severe Asthma)
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