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New Discoveries and Future Trends for Renal Transplantation: From Diagnosis...
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New Discoveries and Future Trends for Renal Transplantation: From Diagnosis to Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 1524

Special Issue Editors

Dr. Panupong Hansrivijit

E-Mail Website
Guest Editor
Brigham and Women's Hospital, Boston, MA, USA
Interests: kidney transplant; chronic kidney disease; dialysis; acute kidney injury; pharmacoepidemiology
Special Issues, Collections and Topics in MDPI journals
Dr. Ayman Al Jurdi

E-Mail Website
Guest Editor Assistant
Massachusetts General Hospital, Boston, MA, USA
Interests: kidney transplant; glomerular disease; glomerulonephritis; transplant immunology; COVID-19 immunology/vaccination
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Kidney transplantation is the ultimate treatment for end-stage kidney disease, given its better survival benefits and quality of life compared to dialysis. However, the process of kidney transplantation still faces numerous challenges, starting from organ allocation, recipient evaluation, immunosuppression, and post-transplant monitoring. Retrospectively, it has been an exciting moment for kidney transplants in the past decade. The outcomes of kidney transplantation have been improving as a result of numerous advances in research and discoveries, such as virtual crossmatching, the development of non-invasive biomarkers, clinical trials for rejection treatment, the prevention of recurrent glomerular disease, novel therapy for cytomegalovirus infection, and targeted cellular therapy for BK nephropathy.

We cordially invite authors and investigators to submit their original research or review articles to this Special Issue, “New Discoveries and Future Trend for Renal Transplantation: From Diagnosis to Treatment”. This serves as an exceptional opportunity for all investigators to share their knowledge on the field of kidney transplantation with the medical community.

Dr. Panupong Hansrivijit
Guest Editor

Dr. Ayman Al Jurdi
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • kidney transplant
  • transplant immunology
  • recurrent glomerular disease
  • clinical trials
  • rejection
  • crossmatching
  • allocation
  • CMV
  • BK nephropathy

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Published Papers (2 papers)

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Research

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10 pages, 921 KiB  
Article
Utilization Trends of Glucose-Lowering Medications Among Adult Kidney Transplant Recipients with Type 2 Diabetes in the United States
by Panupong Hansrivijit, Helen Tesfaye, Deborah J. Wexler, Reza Abdi, Elisabetta Patorno and Julie M. Paik
J. Clin. Med. 2025, 14(2), 651; https://doi.org/10.3390/jcm14020651 - 20 Jan 2025
Cited by 1 | Viewed by 847
Abstract
Background: To date, there are limited studies describing the use of glucose-lowering medications (GLMs) in adult kidney transplant recipients (KTRs), and the uptake of sodium glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP1RAs). Thus, we aimed to evaluate the use of [...] Read more.
Background: To date, there are limited studies describing the use of glucose-lowering medications (GLMs) in adult kidney transplant recipients (KTRs), and the uptake of sodium glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP1RAs). Thus, we aimed to evaluate the use of GLMs, including SGLT2i and GLP1RA, among adult KTRs with type 2 diabetes (T2D). Methods: This is an ecologic study of adult KTR with T2D. Data were sourced from two large U.S. health insurance claim databases from 2014 to 2023. The proportions of any user and incident use of GLMs were reported in percentage. Any use of GLM was defined through prescription claims, and incident use was further defined as the absence of any prior dispensing within the preceding 365 days. Results: From 2014 to 2023, we identified 33,913 adult KTRs with T2D who were prescribed any GLMs. Any use of SGLT2i and GLP1RA increased throughout the study period (0.4% to 14.4% for SGLT2i, and 2.8% to 12.5% for GLP1RA). While insulin was the most frequently used GLM, ranging from 58% to 74%, the usage gradually declined over time. By 2023, SGLT2i and GLP1RA were initiated nearly as frequently as insulin (5.1% for SGLT2i, 5.7% for GLP1RA, and 5.7% for insulin). Compared with insulin initiators, SGLT2i initiators (n = 1009) had a higher prevalence of cardiovascular comorbidities and proteinuria, while GLP1RA initiators (n = 2149) had a higher prevalence of obesity. Conclusions: Any use of both SGLT2i and GLP1RA among KTRs with T2D increased over time with the incident use of SGLT2i and GLP1RA as high as insulin by 2023. Our findings emphasize the need for the effectiveness and safety analysis of SGLT2i and GLP1RA among KTRs with T2D. Full article
(This article belongs to the Special Issue New Discoveries and Future Trends for Renal Transplantation: From Diagnosis to Treatment)
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Review

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16 pages, 1452 KiB  
Review
Does Oxygen Work? Evidence for Oxygenation During Kidney Graft Preservation: A Review
by Andres Calva Lopez, Jose Enrique Robles Garcia, Carlos Andres Yanez Ruiz, Mario Daniel Tapia Tapia, Vanessa Talavera Cobo, Carmina Alejandra Muñoz Bastidas, Bernardino Miñana Lopez and Daniel Sanchez Zalabardo
J. Clin. Med. 2025, 14(6), 1927; https://doi.org/10.3390/jcm14061927 - 13 Mar 2025
Viewed by 176
Abstract
Kidney transplantation (KT) is the gold-standard treatment of end-stage kidney disease (ESKD). Traditional preservation methods, such as static cold storage (SCS), have been replaced by modern and more effective preservation methods, especially hypothermic machine perfusion (HMP). Regardless of improved preservation, ischemia-reperfusion injury (IRI) [...] Read more.
Kidney transplantation (KT) is the gold-standard treatment of end-stage kidney disease (ESKD). Traditional preservation methods, such as static cold storage (SCS), have been replaced by modern and more effective preservation methods, especially hypothermic machine perfusion (HMP). Regardless of improved preservation, ischemia-reperfusion injury (IRI) is inevitable, limiting graft functionality through delayed graft function (DGF) and graft survival. Supplementing the ischemic kidney graft with oxygen during hypothermic preservation has been used in different methods as an attempt to counteract IRI and its effects on graft function and survival. Various oxygenation methods have been studied, from adaptations of classic and well-known preservation strategies, like the addition of oxygen carriers to SCS, or more innovative preservation methods, like hyperbaric oxygenation or retrograde oxygen persufflation. In this review, we will attempt to provide a summary of the available evidence on oxygen carriers, hyperbaric oxygenation, the two-layer method, retrograde oxygen persufflation, and hypothermic oxygenated machine perfusion (HOPE) and discuss the effect these strategies have on kidney graft functionality. Full article
(This article belongs to the Special Issue New Discoveries and Future Trends for Renal Transplantation: From Diagnosis to Treatment)
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