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Review Special Issue Series: Recent Advances in Intensive Care
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Review Special Issue Series: Recent Advances in Intensive Care

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Intensive Care".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 7110

Special Issue Editor

Prof. Dr. Karim Bendjelid

E-Mail Website
Guest Editor
CardioVascular Unit, Intensive Care Division, Geneva University Hospitals, 1205 Geneva, Switzerland
Interests: physiology; cardiology; anesthesiology; intensive care; hemodynamic; echocardiography; ECMO
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Worldwide interest in the management of critically ill patients has escalated significantly in recent decades. 

In this regard, Critical Care Reviews are excellent means by which to share and summarize the art and fundamental science that support intensive care practice. Due to the nature of critically ill patient disease onset and clinical courses, the purpose of the present Special Issue is to publish high-quality scientific papers that address recent advances in several key aspects of critical care and are relevant to a broad range of research. The present Special Issue aims to promote developments in evidence-based practice for the therapy and management of critically ill patients.

Prof. Dr. Karim Bendjelid
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluid rescucitation
  • hemodynamic monitoring
  • cardiogenic shock
  • ARDS and mechanical ventilation
  • sepsis
  • renal failure
  • nutrition and metabolism
  • extracorporeal membrene oxygenation (ECMO)

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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11 pages, 639 KiB  
Article
Association of Albumin-to-D-Dimer Ratio with Mortality in Mechanically Ventilated Intensive Care Patients
by Elif Eygi and Sinem Bayrakci
J. Clin. Med. 2025, 14(11), 3917; https://doi.org/10.3390/jcm14113917 - 3 Jun 2025
Viewed by 475
Abstract
Objectives: Systemic inflammation, coagulopathy, and multiorgan dysfunction are common in critically ill patients and contribute significantly to mortality. Serum albumin and D-dimer are routinely used biomarkers that reflect nutritional status and coagulation activity, respectively. This study aimed to investigate the prognostic value [...] Read more.
Objectives: Systemic inflammation, coagulopathy, and multiorgan dysfunction are common in critically ill patients and contribute significantly to mortality. Serum albumin and D-dimer are routinely used biomarkers that reflect nutritional status and coagulation activity, respectively. This study aimed to investigate the prognostic value of the albumin-to-D-dimer ratio (ADR) in predicting 30-day mortality among patients admitted to the intensive care unit (ICU) and undergoing mechanical ventilation. Methods: This retrospective cohort study included 162 adult patients who underwent invasive mechanical ventilation in the ICU of a tertiary care center between January 2021 and December 2023. Demographic data, comorbidities, and laboratory values—such as serum albumin, D-dimer, lactate, CRP, BUN, creatinine, INR, and platelet count—were recorded within the first 24 h of ICU admission. The albumin-to-D-dimer ratio (ADR) was calculated by dividing serum albumin (g/dL) by D-dimer (μg/mL). The patients were stratified into tertiles based on ADR values: low (<0.95), intermediate (0.95–1.45), and high (>1.45). The association between the ADR and 30-day mortality was analyzed using multivariate logistic regression and receiver operating characteristic (ROC) curve analysis. Results: Of the 162 patients included in the study, 61 (37.7%) died within 30 days. The patients who died had significantly lower ADR values at ICU admission compared to survivors (1.02 ± 0.43 vs. 1.56 ± 0.52, p < 0.001). In the multivariate logistic regression model, a lower ADR remained an independent predictor of 30-day mortality (OR: 0.39; 95% CI: 0.26–0.58; p < 0.001), even after adjusting for age, lactate, creatinine, INR, and other relevant clinical variables. ROC curve analysis demonstrated that the ADR had the highest discriminative performance among all the evaluated parameters, with an AUC of 0.802 (95% CI: 0.728–0.875; p < 0.001). The optimal cut-off value for the ADR was identified as <1.05, yielding a sensitivity of 78.7% and a specificity of 71.4% in predicting 30-day mortality. Conclusions: The ADR is independently associated with 30-day mortality in mechanically ventilated ICU patients and may serve as a useful early prognostic marker. However, given the retrospective, single-center nature of this study, these findings should be interpreted with caution. Further prospective, multicenter studies are needed to validate the clinical utility of the ADR. Full article
(This article belongs to the Special Issue Review Special Issue Series: Recent Advances in Intensive Care)
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Review

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13 pages, 415 KiB  
Review
Review of Temperature Management in Traumatic Brain Injuries
by Kenya Kawakita, Hajime Shishido and Yasuhiro Kuroda
J. Clin. Med. 2024, 13(7), 2144; https://doi.org/10.3390/jcm13072144 - 8 Apr 2024
Cited by 8 | Viewed by 5924
Abstract
Therapeutic hypothermia (TH) for severe traumatic brain injury has seen restricted application due to the outcomes of randomized controlled trials (RCTs) conducted since 2000. In contrast with earlier RCTs, recent trials have implemented active normothermia management in control groups, ensuring comparable intensities of [...] Read more.
Therapeutic hypothermia (TH) for severe traumatic brain injury has seen restricted application due to the outcomes of randomized controlled trials (RCTs) conducted since 2000. In contrast with earlier RCTs, recent trials have implemented active normothermia management in control groups, ensuring comparable intensities of non-temperature-related therapeutic interventions, such as neurointensive care. This change in approach may be a contributing factor to the inability to establish the efficacy of TH. Currently, an active temperature management method using temperature control devices is termed “targeted temperature management (TTM)”. One of the goals of TTM for severe traumatic brain injury is the regulation of increased intracranial pressure, employing TTM as a methodology for intracranial pressure management. Additionally, fever in traumatic brain injury has been acknowledged as contributing to poor prognosis, underscoring the importance of proactively preventing fever. TTM is also employed for the preemptive prevention of fever in severe traumatic brain injury. As an integral component of current neurointensive care, it is crucial to precisely delineate the targets of TTM and to potentially apply them in the treatment of severe traumatic brain injury. Full article
(This article belongs to the Special Issue Review Special Issue Series: Recent Advances in Intensive Care)
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