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Clinical Management of Children and Adolescents with Asthma
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Clinical Management of Children and Adolescents with Asthma

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Pediatrics".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 2816

Special Issue Editors

Prof. Dr. Michele Miraglia del Giudice

E-Mail Website
Guest Editor
Department of Woman, Child and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', Naples, Italy
Interests: allergy; pediatrics; respiratory diseases; asthma; atopy; atopic dermatitis; allergic rhinitis; food allergy; biological drugs; immunotherapy; prevention
Special Issues, Collections and Topics in MDPI journals
Dr. Giorgio Ciprandi

E-Mail Website
Co-Guest Editor
Allergy Clinic, Department of Outpatients, Casa di Cura Villa Montallegro, Genoa, Italy
Interests: allergy; asthma; respiratory infections; immunology; inflammation
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Angela Tosca

E-Mail Website
Co-Guest Editor
Allergy Center, Department of Pediatrics, Istituto Giannina Gaslini, Genoa, Italy
Interests: pediatrics; allergy; asthma; immunology; infections
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Asthma is a chronic condition that affects the airways, resulting in the inflammation and narrowing of air passages. The symptoms of asthma can be mild to severe, and can have a significant impact on a child's quality of life. Children and adolescents with asthma represent a significant and growing population of patients requiring clinical care.

The management of asthma in children and adolescents requires ongoing research and evidence-based practices to improve the quality of care and outcomes for this population. The development of new treatments and interventions, as well as the optimization of existing therapies, is essential for the effective management of asthma in children and adolescents.

This Special Issue, Clinical Management of Children and Adolescents with Asthma, focuses on the latest research and clinical practices related to the diagnosis, treatment, and management of asthma in children and adolescents. It covers a wide range of topics, from the pathophysiology of asthma to the use of pharmacological and non-pharmacological interventions, discussing the current challenges and future prospects of managing asthma in children and adolescents.

Prof. Dr. Michele Miraglia del Giudice
Dr. Giorgio Ciprandi
Dr. Maria Angela Tosca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • asthma
  • children
  • adolescents
  • diagnosis
  • treatment
  • management
  • pharmacological interventions
  • non-pharmacological interventions

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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15 pages, 964 KiB  
Article
Prognostic Factors in Severe Eosinophilic Asthma in a Pediatric Population: A Prospective Cohort Study in Spain
by Clara Padró-Casas, María Basagaña, María del Mar Martínez-Colls, Ignasi García-Olivé, Carlos Pollan Guisasola, Aina Teniente-Serra, Eva Martínez-Cáceres, José Tomás Navarro and Carlos Martínez-Rivera
J. Clin. Med. 2024, 13(23), 7202; https://doi.org/10.3390/jcm13237202 - 27 Nov 2024
Viewed by 881
Abstract
Background/Objectives: The objective of this study was to provide real-world data on prognostic factors in children with severe eosinophilic asthma and to assess biomarkers of outcome. Methods: Fifty-nine children (aged 6–17 years) were included in a prospective cohort attended in a [...] Read more.
Background/Objectives: The objective of this study was to provide real-world data on prognostic factors in children with severe eosinophilic asthma and to assess biomarkers of outcome. Methods: Fifty-nine children (aged 6–17 years) were included in a prospective cohort attended in a Severe Asthma Unit of a tertiary care teaching hospital in Badalona (Barcelona, Spain) and visited at baseline and at 1-year follow-up. Study variables included asthma control using the Asthma Control Test (ACT), forced expiratory volume in one second (FEV1), exacerbation episodes, fractional exhaled nitric oxide (FeNO), and inflammatory biomarkers (blood tests, sputum cells, immunoallergic tests, and levels of cytokines and effector cells in blood and sputum). Results: There were 36 boys and 23 girls, with a mean (SD) age of 11.9 (2.8) years. Uncontrolled severe asthma was diagnosed in 83.1% of cases, with poor symptom control (ACT score < 20) in 52.5%, obstructive pattern (FEV1 < 80% predicted) in 35.6%, and more than one exacerbation in the previous year in 30.5%. The mean duration of asthma was 9.2 (3.6) years. Positive prick tests were recorded in 55 patients, with polysensitization in 6. The mean percentage of sputum eosinophils was 2.5% (3.1%), and the mean eosinophil blood count 543.4 (427.7) cells/µL. Ten patients (32%) showed sputum eosinophilia (>3% eosinophils). Sputum eosinophils did not correlate with blood eosinophils, FeNO, and serum periostin. At 12 months, 13 (22%) children had uncontrolled asthma and 46 (78%) had controlled asthma. Variables significantly associated with uncontrolled asthma were duration of asthma (OR = 1.23, 95% CI 1.01–1.49, p = 0.04) and an ACT score < 20 (OR = 0.80, 95% CI 0.69–0.93, p = 0.004). Lower serum levels of IL-9 appeared to be related with uncontrolled asthma, but statistical significance was not reached. Conclusions: Pediatric severe eosinophilic asthma showed a predominant allergic phenotype with symptomatic disease as a main contributor of uncontrolled asthma at 1 year. Predictive biomarkers of outcome were not identified. Further studies are needed to confirm the present findings especially considering additional variables for a better phenotypic characterization of severe eosinophilic asthma in children and to study in-depth the role of inflammatory biomarkers. Full article
(This article belongs to the Special Issue Clinical Management of Children and Adolescents with Asthma)
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Review

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13 pages, 486 KiB  
Review
Exploring the Interplay between Asthma and Hemoglobinopathies: A Comprehensive Review
by Cristiana Indolfi, Giulio Dinardo, Carolina Grella, Angela Klain, Alessandra Perrotta, Gianluca Mondillo, Maria Maddalena Marrapodi, Fabio Decimo and Michele Miraglia del Giudice
J. Clin. Med. 2024, 13(11), 3263; https://doi.org/10.3390/jcm13113263 - 31 May 2024
Viewed by 1407
Abstract
Asthma, a prevalent chronic respiratory condition characterized by inflammation of the airways and bronchoconstriction, has demonstrated a potential association with hemoglobinopathies such as thalassemia and sickle cell disease (SCD). Numerous studies have highlighted a higher prevalence of asthma among thalassemia patients compared to [...] Read more.
Asthma, a prevalent chronic respiratory condition characterized by inflammation of the airways and bronchoconstriction, has demonstrated a potential association with hemoglobinopathies such as thalassemia and sickle cell disease (SCD). Numerous studies have highlighted a higher prevalence of asthma among thalassemia patients compared to the general population, with rates ranging around 30%. Similarly, asthma frequently coexists with SCD, affecting approximately 20–48% of patients. Children with SCD often experience heightened lower airway obstruction and airway hyper-reactivity. Notably, the presence of asthma in SCD exacerbates respiratory symptoms and increases the risk of severe complications like acute chest syndrome, stroke, vaso-occlusive episodes, and early mortality. Several studies have noted a decrease in various cytokines such as IFN-γ and IL-10, along with higher levels of both IL-6 and IL-8, suggesting an overactivation of pro-inflammatory mechanisms in patients with hemoglobinopathies, which could trigger inflammatory conditions such as asthma. The exact mechanisms driving this association are better elucidated but may involve factors such as chronic inflammation, oxidative stress, and immune dysregulation associated with thalassemia-related complications like chronic hemolytic anemia and iron overload. This review aims to comprehensively analyze the relationship between asthma and hemoglobinopathies, with a focus on thalassemia and SCD. It emphasizes the importance of interdisciplinary collaboration among pulmonologists, hematologists, and other healthcare professionals to effectively manage this complex interplay. Understanding this link is crucial for improving care and outcomes in affected individuals. Full article
(This article belongs to the Special Issue Clinical Management of Children and Adolescents with Asthma)
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