Kidney Transplant Rejection—Pathophysiology, Prevention, and Emerging Therapies

Dear Colleagues,

Acute and chronic rejections of the kidney transplant remain a major cause of allograft failure, resulting in high mortality and morbidities.

There has been a significant improvement in our understanding of the different types of rejections, including T-cell-mediated rejection (TCMR), antibody-mediated rejection (ABMR), and mix rejection (which involves both types). Additionally, a tremendous amount of work has focused on the pathophysiology, prevention, treatment, and outcome of these rejections.

However, despite all these efforts, there is still a significant gap in our understanding and management of these rejections. This gap arises from the fact that the immune system is very complicated and redundant; therefore, a specific targeted therapy may not be enough to subside the immune response associated with rejection, which may lead to chronic changes, allograft dysfunction, or failure.

In this review, we will highlight up-to-date approved data on the pathophysiology, prevention, and therapies (both established and emerging) of kidney transplant rejections.

We aim to provide a source of knowledge to the clinicians and researchers to improve the management of patients and highlight unmet needs.

Dr. Nada Alachkar
Guest Editor

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