Dear Colleagues,

Parkinson disease (PD) is the second most frequent neurodegenerative disease after Alzheimer´s disease, with an age-standardized annual incidence rate of 160 per 100,000 subjects aged 65 years or older. People living with PD present a wide variety of symptoms, including motor symptoms (bradykinesia, rigidity, freezing of gait, etc.), and non-motor symptoms (depression, anxiety, disautonomic features, etc.). As the disease progresses, the effect of the medication decreases over time (wearing off), leading to fluctuating and difficult-to-control symptoms and thus greatly worsening patients’ quality of life. That patients often do not perceive the manifestations of the disease, and therefore cannot accurately report their time course, further complicates therapeutic adjustment.

This Special Issue will include research on the early identification of the various symptoms of Parkinson's disease or their fluctuation via different means, such as new questionnaires or wearables. Research on progression markers aiming to enhance the understanding of these symptoms is also welcome. We welcome papers aimed at improving the clinical control of patients by any means, including innovations in the care process and non-pharmacological therapies.

Dr. Alejandro Rodríguez-Molinero
Dr. Jorge Hernández-Vara
Guest Editors

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• idiopathic Parkinson's disease
• symptom assessment
• dyskinesias
• hypokinesia
• rigidity
• extrapyramidal
• wearing off
• freezing of gait
• non-motor symptoms
• wearable electronic devices
• drug therapy
• electric stimulation therapy
• early medical intervention
• non-pharmacological treatments