Targeted Diagnosis and Treatment of Dementia: Current Concepts and New Horizons

Dear Colleagues,

This Special Issue, titled “Targeted Diagnosis and Treatment of Dementia: Current Concepts and New Horizons”, presents a comprehensive review that focuses on targeted aspects of diagnosing and treating dementia and their relevant issues. Dementia is a complex disorder that is characterized by cognitive decline, behavioral changes, and functional impairments, which heavily impacts patients, their caregivers, and socioeconomic domains. Recent clinical and biological research have opened up new horizons for alleviating the pain felt by patients and reducing the costs of dementia. This review will discuss state-of-the-art findings, emerging domains, and future directions, e.g., the diagnostic tools and criteria relevant to clinical practice, including cognitive, behavioral, and functional assessments, neuroimaging techniques, and the contribution from biomarkers towards a diagnosis. It will also explore the current treatment options that are available, such as pharmacological and non-pharmacological interventions, supportive care strategies, and dynamic pre-symptomatic and para-symptomatic prevention . Developing concepts in highly prevalent  late-onset dementia will include its high multimorbidity, multisyndromal presentation, heterogeneity, the interaction between its behavioral, neurological, neuropsychological, psychiatric, geriatric, systemic, and social components, and its complex effect on diagnostic approaches, treatment, case management, and potential remediability. Relevant pathophysiological models, emerging disease-modifying treatments, and future directions of research are welcome. This review aims to help in consolidating the essential and appropriate steps for diagnostic work-up, treatment decisions, and follow-up.

Dr. Eli Wertman
Guest Editor

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• dementia
• pre-dementia
• diagnosis
• targeted therapies
• cognitive assessment
• behavioral syndromes neuroimaging
• multimorbidity
• pharmacological interventions
• non-pharmacological approaches
• case management
• supportive care
• remediability