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Advances in Aging and Obstructive Sleep Apnea
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Advances in Aging and Obstructive Sleep Apnea

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Otolaryngology".

Deadline for manuscript submissions: closed (30 October 2024) | Viewed by 5600

Special Issue Editors

Dr. Peter M. Baptista

E-Mail Website
Guest Editor
Department of Otolaryngology Head and Neck Surgery, Clínica Universitaria de Navarra, 31008 Pamplona, Spain
Interests: obstructive sleep apnea surgery; endoscopic sinus surgery; rhinology; snoring
Dr. Guillermo Plaza

E-Mail Website
Guest Editor
Department of Otolaryngology, Hospital Universitario de Fuenlabrada, Universidad Rey Juan Carlos, 28943 Madrid, Spain
Interests: sleep apnea; sleep endoscopy; rhinology; dacryocystorhinostomy
Dr. Carlos O’Connor Reina

E-Mail Website
Guest Editor
Department of Otolaryngology, Hospital Quiron Salud Marbella, 29603 Marbella, Spain
Interests: sleep apnea; sleep medicine; myofunctional therapy; sleep disordered breathing; sleep surgery; oropharyngeal exercise
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Obstructive sleep apnea is a very prevalent disease that affects millions of people of all ages. It is known to be much more frequent in men than in women, and women start to show signs of OSA in the perimenopausal stage, linked to hormonal changes. It would be interesting to have a special issue reflecting how sleep apnea evolves according to age, with targeted information showing if it is developed in childhood or a disorder that begins in adulthood. Furthermore, we aim to explore whether there is a need to redefine the pathophysiology of OSA according to age. With an aging population, more information is needed on the specific traits of OSA in the elderly population and what steps should be taken to treat OSA.

Dr. Peter M. Baptista
Dr. Guillermo Plaza
Dr. Carlos O’Connor-Reina
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obstructive sleep apnea
  • childhood
  • puberty
  • adult
  • elderly

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Published Papers (3 papers)

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8 pages, 715 KiB  
Article
Comparative Analysis of Ketorolac and Parecoxib for Postoperative Pain Management in Uvulopalatopharyngoplasty
by Cheng-Yu Hsieh, Chuan-Hung Sun, Chung-Ching Lin and Yi-Fan Chou
J. Clin. Med. 2024, 13(15), 4422; https://doi.org/10.3390/jcm13154422 - 28 Jul 2024
Cited by 1 | Viewed by 1759
Abstract
Background/Objectives: Uvulopalatopharyngoplasty (UPPP) is a prevalent surgical procedure for treating obstructive sleep apnea. Effective postoperative pain management is crucial for patient comfort and recovery. This study aimed to compare the analgesic efficacies of parecoxib and ketorolac in patients undergoing UPPP. Methods: A prospective, [...] Read more.
Background/Objectives: Uvulopalatopharyngoplasty (UPPP) is a prevalent surgical procedure for treating obstructive sleep apnea. Effective postoperative pain management is crucial for patient comfort and recovery. This study aimed to compare the analgesic efficacies of parecoxib and ketorolac in patients undergoing UPPP. Methods: A prospective, randomized, double-blind study was conducted on 83 patients who received either parecoxib (40 mg intravenously every 12 h) or ketorolac (30 mg intravenously every 8 h) for 2 days following UPPP. Postoperative pain and swallowing discomfort were assessed using visual analog scales (VASs) at 4, 24, 48, and 72 h. The time to resume eating and adverse reactions were also recorded. Results: At 24 and 48 h postoperatively, the mean VAS score was significantly higher in the ketorolac group compared to the parecoxib group (5.0 ± 2.3 vs. 3.6 ± 2.2, p = 0.005 and 3.9 ± 2.2 vs. 2.5 ± 1.7, p < 0.001, respectively). However, no significant difference in the mean VAS scores was observed between the two groups at 72 h postoperatively. With regards to postoperative swallowing pain, the ketorolac group exhibited significantly higher mean VAS scores than the parecoxib group at 4, 24, 48, and 72 h postoperatively. Conclusions: Intravenous parecoxib may offer superior analgesic benefits in the early postoperative period, particularly in alleviating swallowing pain, compared to ketorolac in UPPP procedures. Full article
(This article belongs to the Special Issue Advances in Aging and Obstructive Sleep Apnea)
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17 pages, 2680 KiB  
Systematic Review
The Role of Rapid Maxillary Expansion in the Management of Obstructive Sleep Apnoea: Monitoring Respiratory Parameters—A Systematic Review and Meta-Analysis
by Aniruddh Hariharan, Susana Muwaquet Rodriguez and Tawfiq Hijazi Alsadi
J. Clin. Med. 2025, 14(1), 116; https://doi.org/10.3390/jcm14010116 - 28 Dec 2024
Viewed by 1505
Abstract
Background/Objectives: Obstructive sleep apnoea (OSA) is a sleep-related breathing condition that involves the presence of episodic disruptions to the sleeping pattern due to partial or complete airway obstruction. There are a range of treatment options that exist to alleviate the symptoms of this [...] Read more.
Background/Objectives: Obstructive sleep apnoea (OSA) is a sleep-related breathing condition that involves the presence of episodic disruptions to the sleeping pattern due to partial or complete airway obstruction. There are a range of treatment options that exist to alleviate the symptoms of this condition including CPAP, mandibular advancement, and maxillary expansion techniques. This systematic review and meta-analysis of published articles aims to determine if rapid maxillary expansion (“RME”) is an effective treatment option in the management of OSA, using quantitative parameters of AHI and SpO2. Methods: An exhaustive review of the literature was conducted on EBSCO, PubMed, and Scopus databases. The PICO question for the systematic review was “Can rapid maxillary expansion be used as a viable treatment option using comparative AHI and SpO2 parameters in the management of obstructive sleep apnoea?” A meta-analysis was also performed and the software used to carry out the meta-analysis was R 4.3.2 (R Core Team (2013)). Results: From the initial search, 62 articles were found and a further 4 articles were obtained from manual findings. Nine articles were included in the final systematic review and meta-analysis. Eight of the studies concluded that RME was successful to varying degrees in the management of OSA across both outcome variables assessed. The meta-analysis indicated that RME is an effective treatment option in the management of adult and paediatric OSA with the improvement of both parameters. The paediatric OSA sample with specific pre-treatment anatomical presentation (clear maxillary deficiency, narrow hard palate with crossbite) showed a noted resolution of OSA following RME at a pre-pubertal age, indicating that RME can be employed as a genuine treatment option for paediatric OSA as suggested by theory. Conclusions: The systematic review and meta-analysis provided sufficient significant data in favour of the alternative hypothesis to indicate that RME is an effective treatment option in the management of obstructive sleep apnoea, in terms of the AHI reduction and SpO2 increase. Full article
(This article belongs to the Special Issue Advances in Aging and Obstructive Sleep Apnea)
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10 pages, 1652 KiB  
Case Report
Tonsillectomy May Not Be the Answer in All OSA Cases
by Belén Bargagna, Carlos O’Connor-Reina, Laura Rodriguez-Alcala, Andrés Navarro, Gabriela Bosco, Nuria Pérez-Martín, Peter M. Baptista, Marina Carrasco-Llatas and Guillermo Plaza
J. Clin. Med. 2024, 13(21), 6456; https://doi.org/10.3390/jcm13216456 - 28 Oct 2024
Viewed by 1859
Abstract
Tonsillectomy is considered the standard of care in patients with obstructive sleep apnea (OSA) and large tonsils; however, there are selected cases where this procedure should not be considered. We present two patients with tonsil grade 4 and severe OSA where tonsillectomy was [...] Read more.
Tonsillectomy is considered the standard of care in patients with obstructive sleep apnea (OSA) and large tonsils; however, there are selected cases where this procedure should not be considered. We present two patients with tonsil grade 4 and severe OSA where tonsillectomy was not the solution for their problem and could be a superfluous procedure. In our experience, a preoperatory drug-induced sleep endoscopy (DISE) and proper patient phenotyping will prevent this type of surgical failure. Full article
(This article belongs to the Special Issue Advances in Aging and Obstructive Sleep Apnea)
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