Rheumatic Diseases: Molecular Mechanisms and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 December 2024) | Viewed by 286
Special Issue Editor
Interests: heumatology; systemic sclerosis; osteoarthritis; vasculitis; clinical immunology; clinical nutrition
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Rheumatic diseases encompass a diverse group of conditions characterized by autoimmune-mediated inflammation affecting multiple organs. Understanding their molecular mechanisms is crucial for developing effective treatments. Research has unveiled intricate pathways involving dysregulated immune responses, aberrant cytokine signaling, and genetic predispositions. Targeting these mechanisms has led to the development of innovative therapies such as biologic agents and small molecule inhibitors. Biologics like TNF-alpha inhibitors and interleukin-6 receptor antagonists disrupt inflammatory pathways, providing relief for conditions like rheumatoid arthritis and ankylosing spondylitis. Small molecule inhibitors, including Janus kinase (JAK) inhibitors, modulate intracellular signaling cascades to mitigate inflammation in diseases like psoriatic arthritis. Additionally, emerging treatments focus on immune regulation and tissue repair mechanisms to address the underlying pathology more effectively. By elucidating these molecular pathways and developing targeted therapies, researchers aim to improve outcomes and quality of life for individuals living with rheumatic diseases.
In this context, we anticipate and invite your submissions on, but not limited to, the following topics:
- Dysregulated immune responses and Immune modulation strategies in rheumatic diseases;
- Aberrant cytokine signaling and its role in rheumatic disease pathogenesis;
- Genetic predispositions and rheumatic disease susceptibility;
- Role of biologics Small molecule inhibitors in treating rheumatic diseases;
- The biomarkers, pathogenesis, and Targeted therapy of common rheumatic diseases (Rheumatoid arthritis, Systemic lupus erythematosus, Polymyositis and dermatomyositis, Sjögren’s syndrome, Osteoarthritis, etc.).
Dr. Mislav Radić
Guest Editor
Manuscript Submission Information
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Keywords
- rheumatic disease
- molecular mechanisms
- treatment
- cytokine signaling
- tsDMARDs
- anti-fibrotics
- bDMARDs
- genetic predispositions
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