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Gastric Cancer: Clinical Challenges and New Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (25 October 2024) | Viewed by 1451

Special Issue Editors


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Guest Editor
Department of Surgery, Brandenburg Medical School, University Hospital Brandenburg/Havel, 14770 Brandenburg, Germany
Interests: gastric cancer; upper GI (tract); gender medicine; acute abdominal pain; appendicitis; emergency surgery; colorectal surgery; surgical teaching
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Guest Editor
Department of General, Abdominal, Vascular and Transplant Surgery, Otto-von-Guericke University with University Hospital, 39120 Magdeburg, Germany
Interests: immune response of Helicobacter pylori infection as a model of GI infection; mucosal immunology/bacterially induced inflammation; TFF peptide within the stomach/gastric mucosa as well as the whole GI tract; research on clinical care; surgical quality assurance; acute pancreatitis; oncosurgery; cancer genetics; gastrointestinal stroma tumors and further rare tumor lesions/growth; coincidence of malignant tumor lesions/growth; surgical aspects of gender medicine; surgical teaching/research on surgical teaching; hospital, quality, and risk management; scientific publishing in human medicine; editorial assistance
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of General, Abdominal, Vascular and Transplant Surgery, University Hospital Magdeburg, Magdeburg, Germany
Interests: liver metastasis; liver cancer; colorectal cancer; pancreatic cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Surgically determined treatment and care of gastric cancer has experienced great development for more than 15 years.

In particular, the implementation of neoadjuvant chemotherapy has led to substantial progress in surgical therapy and its early postoperative and long-term oncosurgical outcome.

In addition to randomized controlled trials, prospective multicenter observational studies on daily surgical practice for the purpose of quality assurance can be considered a valuable contribution to research and surgical care.

In addition, surgical specimens and tumor tissue have been better characterized step-by-step, e.g., with regard to MSI (in)stability, for a more personalized therapy, focussing increasingly on i) novel antineoplastic substances and their combinations, ii) targeted therapy based on antibodies, and iii) immune-regulating or -modulating drugs and medication, such as check-point inhibitors (depending on the features of the tumor tissue).

From a purely surgical point of view, the surgical potential of recurrent and metastatic tumor growth (i.e., hepatic and peritoneal metastases) as well as prospects for palliative tumor resections have become of great interest in the surgical community. Furthermore, multi-modal treatment concepts as well as gender- and BMI-dependent specifics may be of particular interest with regard to patient-, diagnosis-, tumor tissue- and surgical treatment-associated characteristics (such as perioperative factors and parameters).

Taken together, all the abovementioned aspects are potential topics of interest for this Special Issue of the Journal of Clinical Medicine. We invite the submission of papers focusing on the following topics:

  • Evaluating original data;
  • Summarizing and discussing available data by means of a meta-analysis, systematic or narrative reviews.

Dr. Claus Wilhelm Schildberg
Prof. Dr. Frank Meyer
Prof. Dr. Aristotelis Perrakis
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastric cancer
  • curative/palliative resection
  • neoadjuvant chemothrapy
  • multimodal treatment
  • transthoracically/transhiatally extended gastrectomy
  • histopathological investigation
  • frozen section
  • MSI status
  • BMI-specific aspects of gastric cancer surgery
  • personalized therapy
  • targeted therapy

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Published Papers (1 paper)

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Research

14 pages, 2321 KiB  
Article
Gastric Epithelial Neoplasms in Patients with Pulmonary Arterial Hypertension Receiving Continuous Intravenous Prostacyclin Therapy
by Tomohiko Mannami, Takehiro Tanaka, Hiroto Shimokawahara, Kyosuke Horikawa, Yoko Shinno, Tsuyoshi Umekawa, Tsukasa Sakaki, Yasushi Fukumoto, Shin’ichi Shimizu, Isao Nozaki, Aiko Ogawa and Hiromi Matsubara
J. Clin. Med. 2025, 14(3), 791; https://doi.org/10.3390/jcm14030791 - 25 Jan 2025
Viewed by 1060
Abstract
Background: The association of intravenous prostacyclin therapy, essential for improving prognosis and survival in pulmonary arterial hypertension (PAH), with gastric epithelial neoplasms is uncertain. This study aimed to analyze the clinicopathologic features of gastric neoplasms in patients with PAH undergoing continuous intravenous [...] Read more.
Background: The association of intravenous prostacyclin therapy, essential for improving prognosis and survival in pulmonary arterial hypertension (PAH), with gastric epithelial neoplasms is uncertain. This study aimed to analyze the clinicopathologic features of gastric neoplasms in patients with PAH undergoing continuous intravenous prostacyclin therapy. Methods: We screened the registry of patients with pulmonary hypertension who visited the NHO Okayama Medical Center. Of the patients with PAH managed between January 2003 and December 2022, those who underwent esophagogastroduodenoscopy (EGD) were assessed for gastric neoplasms. Their clinical, endoscopic, and histopathological data were reviewed. Results: Among the 186 patients with PAH, 56 underwent EGD, revealing 4 patients (aged 37–50 years) with gastric epithelial neoplastic lesions. All four patients received continuous intravenous prostacyclin therapy for a median of 151 months. Of the 98 patients who received prostacyclin, 28 patients underwent EGD; the incidence of gastric epithelial neoplasms was 4.1% (4/98) and the endoscopic detection rate was 14.3% (4/28). All patients had multiple tumors against a background of hypertrophic gastropathy (histologically being foveolar epithelial hyperplasia), with shared features of distal location, elevated morphology, and absent submucosal invasion. However, lymph node metastasis was observed in one lesion. By immunohistochemistry, the tumors exhibited gastric-predominant mucus phenotype and were managed by surgical or endoscopic resection without recurrence. Conclusions: The consistent clinicopathologic features of these cases suggest an association between continuous intravenous prostacyclin therapy and the development of hypertrophic gastropathy with potential progression to gastric epithelial neoplasia. Further prospective clinical trials are warranted to ensure safer prostacyclin use. Full article
(This article belongs to the Special Issue Gastric Cancer: Clinical Challenges and New Perspectives)
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