Personalized Therapy and Clinical Outcome for Vasculitis
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology & Rheumatology".
Deadline for manuscript submissions: 25 August 2026 | Viewed by 1654
Special Issue Editor
Interests: rheumatology and immunology; autoimmune diseases; vasculitis; SLE; connective tissue diseases; interstitial lung disease; rheumatoid arthritis; capillaroscopy; personalized medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Systemic vasculitides are a heterogeneous group of immune-mediated diseases characterized by inflammation of blood vessels, leading to tissue ischemia, organ dysfunction, and significant morbidity. They are traditionally classified according to the size of the affected vessels into small, medium, or large vessel vasculitis. Although many forms are rare, they often present with severe, life-threatening manifestations and multi-organ involvement, requiring complex clinical management. Despite advances in classification and therapeutic strategies, the management of vasculitis remains challenging. The heterogeneity of clinical presentation, the lack of robust biomarkers of disease activity, and the frequent need for multidisciplinary care complicate treatment decisions. Conventional immunosuppressive regimens have improved survival, but relapses, treatment-related toxicity, and incomplete disease control are still common. In recent years, the concept of personalized therapy has gained increasing relevance. Advances in immunopathogenesis, the identification of novel biomarkers, and the integration of imaging and genetic/epigenetic data have paved the way for individualized treatment strategies. Tailoring therapy to disease subsets, serological profiles, and patient characteristics holds promise for optimizing efficacy while minimizing adverse effects. Equally important is the evaluation of long-term clinical outcomes, including organ damage, quality of life, and treatment sustainability, which are essential to guide therapeutic decisions. This Special Issue, entitled “Personalized Therapy and Clinical Outcome for Vasculitis”, aims to provide a comprehensive overview of current knowledge and future perspectives in the field. Contributions will address innovative therapeutic approaches, prognostic markers, and outcome measures, highlighting the potential of personalized medicine to transform clinical practice. By integrating translational research with real-world clinical data, this collection seeks to advance our understanding of vasculitis and support the development of individualized management pathways that improve patient outcomes.
Dr. Giulia Cassone
Guest Editor
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Keywords
- immune-mediated systemic vasculitis
- personalized therapy
- treatment
- outcome
- biomarkers
- risk factors
- management
- multidisciplinary care
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