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Cancers of the Pelvic Organs: Contemporary Management and Actions for Improving Patients’ Quality of Life: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: 15 December 2025 | Viewed by 606

Special Issue Editors


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Guest Editor
1. Faculty of Health Science, Jagiellonian University Medical College, Skawinska 8, 31-066 Krakow, Poland
2. Department of Gynecology and Obstetrics with Gynecological Oncology, Specialized Ludwik Rydygier Hospital, ul. Zlotej Jesieni 1, 31-826 Krakow, Poland
Interests: incontinence; pelvic floor disorders; physiotherapy; obesity; physical activity; urogyneacology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Department of Gynecology and Obstetrics, Andrzej Frycz Modrzewski Krakow University, ul. Gustawa Herlinga-Grudzińskiego 1, 30-705 Kraków, Poland
2. Department of Gynecology and Obstetrics with Gynecological Oncology, Specialized Ludwik Rydygier Hospital, ul. Zlotej Jesieni 1, 31-826 Krakow, Poland
Interests: gynecological oncology; urogynecology; endometrial cancer; ovarian cancer; vulvar cancer; cervical cancer; urodynamics; incontinence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to invite you to the second edition of our Special Issue, published in 2023, entitled “Cancers of the Pelvic Organs: Contemporary Management and Actions for Improving Patients’ Quality of Life”. In the first edition, we published eight articles, both original and reviews, focused on issues such as the treatment of ovarian, endometrial, bladder and prostate cancer. On the one hand, the articles concerned surgical treatment including robotic treatment and chemotherapy. On the other hand, they discussed the possibility of physiotherapeutic support for patients. The work also included an analysis of complications resulting from the treatment used.

Bearing in mind that neoplasms affect a large population of women and men worldwide each year, it is important to search for new, advanced diagnostic and therapeutic techniques that would allow for early cancer diagnosis, satisfactory treatment results, and improvements in patients’ quality of life.

The second edition of our Special Issue aims to further explore and present the latest achievements and analyses in the field of managing neoplastic diseases of the pelvic organs both in women and men, i.e., the lower urogenital system and the lower gastrointestinal tract. In particular, we invite professionals dealing with the issues of modern methods in oncological diagnosis and treatment, with special emphasis on the problem of treatment complications, methods of their prevention, oncofertility, assessment of patients’ quality of life, supportive therapies, new technologies affecting the quality of life, life expectancy, and overall survival, as well as physiotherapeutic and psychological support in oncological treatment. For that reason, we extend our invitation to a broad, multidisciplinary team consisting of oncologists, gynecologic oncologists, oncologic urologists, urogynecologists, urologists, physiotherapists, psychologists, radiotherapists, clinical oncologists, and surgeons. You are welcome to submit/We are interested in publishing original research papers, reviews, systematic reviews, and meta-analyses.

We hope that our Special Issue will become a platform for the exchange of experiences in the field of evidence-based medicine for better treatment of oncological diseases of the pelvic area. Thus, hopefully, we will be able to improve the quality of patients’ lives together.

We look forward to receiving your contributions.

Dr. Agnieszka Mazur-Bialy
Dr. Marcin Opławski
Guest Editors

Manuscript Submission Information

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Keywords

  • gynecological cancers, e.g., endometrial, cervical, ovarian, and vulvar cancer
  • urogenital tract cancers in men, e.g., bladder, prostate, penis, and testicular cancer
  • gastrointestinal cancers
  • complications of oncological treatment, e.g., pelvic floor disfunction: incontinence and POP
  • patients’ quality of life and possibilities of its improvement
  • oncofertility
  • physiotherapy
  • oncology treatment (modern surgical approach, including robotics, chemotherapy, radiotherapy, immunotherapy, targeted therapy)
  • biological basis of pathogenesis and cancer progression, biological markers, anticancer agents
  • cancer prophylaxis and prevention—current trends and opportunities

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Published Papers (1 paper)

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13 pages, 3988 KiB  
Case Report
Very Late-Onset Serious Chronic Adverse Effects After Radical Chemoradiotherapy for Anal Canal Cancer
by Pavel Vitek, Jiri Kubes, Barbora Ondrova and Alexandra Haas
J. Clin. Med. 2025, 14(11), 3841; https://doi.org/10.3390/jcm14113841 - 29 May 2025
Viewed by 316
Abstract
Radical chemoradiotherapy has been used as a frontline treatment for squamous cell cancer of the anus for the last 30–40 years. Considerable acute and chronic adverse effects have been observed following radiotherapy using 2D and 3D techniques. A case of very late-onset severe [...] Read more.
Radical chemoradiotherapy has been used as a frontline treatment for squamous cell cancer of the anus for the last 30–40 years. Considerable acute and chronic adverse effects have been observed following radiotherapy using 2D and 3D techniques. A case of very late-onset severe chronic toxicity in a patient 26 years after radiotherapy is presented. The patient underwent radical chemoradiotherapy for squamous anal cancer stage T3N3M0 in 1998. In the anal region, cumulative doses up to 77.6 Gy (including electron boost) were administered. Durable complete regression of the disease was achieved. Fourteen years after treatment, the patient developed vast fibroatrophy of the anus and perineum, progressing within the subsequent four years to necrosis and sphincter loss. Twenty years after treatment, the asymptomatic osteonecrotic foci in the left femur appeared on MRI scans. Despite two courses of hyperbaric oxygen treatment, the fibroatrophy and subsequent necrosis of soft tissues remained progressive, but the osteonecrosis was stable. Twenty-six years after treatment, the progressive changes induced symptomatic osteomyelitis of the ischium and pubic bone. The patient now requires permanent supportive treatment. The presented case is exceptional in the very late-onset typical chronic adverse effects developing after non-conformal radiotherapy administered at high doses as part of contemporary treatment protocols. There is little evidence regarding the late onset of chronic adverse effects, since the follow-up period is usually shorter than that of the case presented. Moreover, a significant portion of patients do not survive to reach the late-onset period of adverse effects. The presented case shows that there may be long-term survivors of anal cancer in the population who were treated with outdated techniques and who still carry a risk of late-onset severe, progressive adverse effects. Full article
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