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Differential Effects of Bariatric Surgery (BS) and Endoscopic Bariatric Therapy...
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Differential Effects of Bariatric Surgery (BS) and Endoscopic Bariatric Therapy (EBT) on Long and Short-Term Metabolic Outcomes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1048

Special Issue Editor

Dr. Mohamad Mokadem

E-Mail Website
Guest Editor
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Interests: Roux-en-Y gastric bypass; obesity; weight loss

Special Issue Information

Dear Colleagues,

Obesity has become a global health concern, leading to an increased demand for bariatric interventions. Bariatric surgery and endoscopic bariatric therapy have emerged as effective treatments; however, the existing literature lacks a comprehensive comparison of their outcomes, particularly in terms of disparities and differential effects:

  • Deficiencies in Comparative Studies: Existing comparative studies often lack standardization in outcome measures, follow-up periods, and patient selection criteria, leading to inconclusive or conflicting results.
  • Research Gaps in Long-Term Comparative Data: There is a paucity of long-term comparative data assessing the sustained efficacy and safety profiles of bariatric surgery versus endoscopic bariatric therapy.
  • Patient-Centric Outcomes: Limited research has delved into patient-reported outcomes, quality of life measures, and psychosocial impacts, all of which are crucial in understanding the holistic effects of these interventions.

Objectives:

Addressing Methodological Inconsistencies: This Special Issue aims to critically evaluate and address the methodological inconsistencies in existing comparative studies, thereby paving the way for more conclusive findings.

Exploring Disparities in Subpopulations: We will evaluate the differential effects of bariatric interventions across diverse demographic and clinical subpopulations to unravel disparities in outcomes.

Conclusion: By shedding light on the disparities and differential effects of bariatric surgery and endoscopic bariatric therapy, this Special Issue endeavors to bridge existing knowledge gaps and provide valuable insights for clinicians, researchers, and policy makers in the field of obesity management.

We invite the submission of original research articles, systematic reviews, meta-analyses, and theoretical papers that contribute to deepening our collective understanding of the differences in outcomes between bariatric surgery and endoscopic bariatric therapy. Submissions addressing methodological refinements, long-term comparative data, patient-reported outcomes, and disparities in subpopulations are particularly encouraged.

Dr. Mohamad Mokadem
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • bariatric surgery
  • endoscopic bariatric therapy
  • metabolic surgery
  • weight loss
  • metabolism
  • weight management

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Published Papers (2 papers)

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Research

14 pages, 434 KiB  
Article
Outcomes Comparison Between Primary and Revisional Duodenal Switch in Patients with a BMI Greater than 55 kg/m2
by Lorna A. Evans, Jorge Cornejo and Enrique F. Elli
J. Clin. Med. 2025, 14(10), 3426; https://doi.org/10.3390/jcm14103426 - 14 May 2025
Viewed by 198
Abstract
Background: Revisional bariatric surgery for recurrent weight gain is becoming more common, though it carries higher risks and may be less effective than primary bariatric surgery. This study compares clinical outcomes between primary and revisional duodenal switch (DS) in patients with a [...] Read more.
Background: Revisional bariatric surgery for recurrent weight gain is becoming more common, though it carries higher risks and may be less effective than primary bariatric surgery. This study compares clinical outcomes between primary and revisional duodenal switch (DS) in patients with a body mass index (BMI) > 55 kg/m2. Methods: A retrospective cohort study was conducted on 20 patients who underwent either primary or revisional duodenal switch (DS) surgeries, including biliopancreatic diversion with duodenal switch (BPDDS) and Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy (SADI-s), between January 2015 and December 2023. Revisional DS was defined as the conversion from Sleeve Gastrectomy (SG) to either BPDDS (C-BPDDS) or SADI-S (C-SADI-S). Perioperative and postoperative variables were analyzed. A statistical analysis was performed using chi-square and McNemar tests for categorical variables and Student’s t-test for continuous variables. A p-value of <0.05 was considered significant. Results: Eleven primary DS patients (six BPDDS, five SADI-s) and nine revisional DS patients (five C-BPDDS, four C-SADI-s) were included. The revisional group had a slightly higher preoperative BMI (57.56 ± 5.92 kg/m2 vs. 55.93 kg/m2 ± 6.91 kg/m2). Although operative times were shorter in the revisional group (153.20 ± 53.26 vs. 193.27 ± 46.79 min), the length of stay was longer (2.70 ± 1.25 vs. 2.18 ± 1.16 days). Primary DS patients experienced three minor late complications (dehydration, nephrolithiasis), whereas the revisional group had one major complication (internal hernia requiring reoperation). At the 12-month follow-up, both groups demonstrated similar outcomes in terms of percentage of total weight loss (%TWL) (primary DS: 25.25% ± 12.38 vs. revisional DS: 30.31% ± 10.79) and percentage of excess weight loss (%EWL) (primary DS: 48.41% ± 22.93 vs. revisional DS: 53.24% ± 14.48). Conclusions: Revisional DS was associated with shorter operation times and similar weight loss to primary DS. Additionally, it was accomplished safely and led to adequate and sustained weight loss in patients with a BMI greater than 55 kg/m2. Full article
(This article belongs to the Special Issue Differential Effects of Bariatric Surgery (BS) and Endoscopic Bariatric Therapy (EBT) on Long and Short-Term Metabolic Outcomes)
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15 pages, 2798 KiB  
Article
A Western-Style Diet Influences Ingestive Behavior and Glycemic Control in a Rat Model of Roux-en-Y Gastric Bypass Surgery
by C. Warner Hoornenborg, Edit Somogyi, Jan E. Bruggink, Christina N. Boyle, Thomas A. Lutz, Marloes Emous, André P. van Beek and Gertjan van Dijk
J. Clin. Med. 2025, 14(8), 2642; https://doi.org/10.3390/jcm14082642 - 11 Apr 2025
Viewed by 352
Abstract
Background: Roux-en-Y gastric bypass (RYGB) surgery results in weight reduction and decreased energy intake and can ameliorate type 2 diabetes. These beneficial effects are usually attributed to changes in hunger and satiety and relatively rapid improvements in glycemic control, but these effects [...] Read more.
Background: Roux-en-Y gastric bypass (RYGB) surgery results in weight reduction and decreased energy intake and can ameliorate type 2 diabetes. These beneficial effects are usually attributed to changes in hunger and satiety and relatively rapid improvements in glycemic control, but these effects may depend on dietary adherence. The aim of this study is to investigate the relatively early effects of RYGB surgery on weight reduction (by focusing on eating patterns) and glycemic control in rats subjected to a healthy maintenance diet or an unhealthy Western-style diet. Methods: Rats were fed a high-fat diet with added sucrose (HF/S) or a low-fat (LF) diet. Body weight, high-resolution tracking of meal-related parameters, and glucose regulation after overnight fasting and during a mixed meal tolerance test (MMTT; 2 mL sweet/condensed milk) were measured before and after RYGB (RYGB+) or sham surgery (RYGB−). Results: HF/S feeding led to an increased body weight just before RYGB surgery, but it also caused enhanced weight loss following RYGB, which led to similar body weights in the HF/S and LF diet groups twenty-four days post-operatively. RYGB surgery and diet dependently and independently influenced meal-related parameter outcomes, where both RYGB+ and HF/S feeding resulted in shorter meal duration (p < 0.01), higher ingestion rates (p < 0.001), and increased satiety ratio (p < 0.05), especially in the HF/S diet group subjected to RYGB. While RYGB surgery generally improved baseline glycemic parameters including HOMA-IR (p < 0.01), it often interacted with diet to affect MMTT-induced hyperglycemia (p < 0.05), beta-cell sensitivity (p < 0.01), and the insulinogenic index (p < 0.01), with the LF rats overall maintaining better glycemic control than the HF/S-fed rats. Conclusions: This study shows the importance of controlling diet after RYGB surgery, as diet type significantly influences ingestive behavior, post-prandial glucose regulation, beta-cell sensitivity, and glucose tolerance after RYGB. Full article
(This article belongs to the Special Issue Differential Effects of Bariatric Surgery (BS) and Endoscopic Bariatric Therapy (EBT) on Long and Short-Term Metabolic Outcomes)
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