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Novel Insights for Imaging and Therapy in Maternal and Fetal Medicine

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: closed (20 February 2026) | Viewed by 790

Special Issue Editor


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Guest Editor
Centre Hospitalier Universitaire Brugmann, Brussels, Belgium
Interests: prenatal imaging; prenatal diagnosis; fetal virtual autopsy; preeclampsia; macrosomia; preterm birth

Special Issue Information

Dear Colleagues,

From measuring nucal translucency to NIPT for early aneuploidy screening and from second-trimester uterine artery pulsatility to the first-trimester screening for preeclampsia and its prevention using asprin, maternal and fetal medicine are at the forefront of key advancements in early diagnosis. Owing to technological improvements in ultrasound and magnetic resonance imaging and the increasing performance of whole-exome sequencing, numerous congenital diseases, malformations, and syndromes are currently or soon to be diagnosed much earlier on during pregnancy, even during the first trimester. These possibilities may lead to the development of new therapies or management protocols, such as the prevention of preterm birth, fetal growth restriction, macrosomia, etc. In this Special Issue, we invite authors to submit papers on new maternal and fetal imaging technologies, advances in prenatal diagnosis, and new insights for maternal and fetal treatment. 

Dr. Xin Kang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prenatal imaging
  • prenatal diagnosis
  • fetal virtual autopsy
  • preeclampsia
  • macrosomia
  • preterm birth
  • pelvic floor

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Published Papers (1 paper)

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Research

12 pages, 1231 KB  
Article
Three-Dimensional Postmortem Ultrasound of the Fetal Corneal Volume to Estimate Postmortem Interval
by Patricia Ibarra Vilar, Dominique A. Badr, Laura De Luca, Teresa Cos Sanchez, Jacques C. Jani and Xin Kang
J. Clin. Med. 2026, 15(5), 1865; https://doi.org/10.3390/jcm15051865 - 28 Feb 2026
Viewed by 363
Abstract
Objectives: To develop and prospectively validate a predictive model to estimate the fetal postmortem interval (PMI) using three-dimensional postmortem ultrasound (3D PM-US) measurements of corneal and ocular volumes. Methods: Single-center study including fetuses ≥ 20 weeks’ gestation with known time of [...] Read more.
Objectives: To develop and prospectively validate a predictive model to estimate the fetal postmortem interval (PMI) using three-dimensional postmortem ultrasound (3D PM-US) measurements of corneal and ocular volumes. Methods: Single-center study including fetuses ≥ 20 weeks’ gestation with known time of death after feticide. A retrospective training cohort (n = 63; November 2022–July 2023) and a prospective validation cohort (n = 28; February–August 2025) were used. Corneal and ocular volumes were measured using the VOCAL™ rotation multiplanar technique; the cornea-to-eyeball volume ratio was calculated for each case. Automated machine learning (AutoML) was used to develop and validate a gradient boosting machine (GBM) model. Model performance was evaluated using the root mean squared error (RMSE), mean absolute error (MAE), and coefficient of determination (R2). Results: Ninety-four fetuses were included; three were excluded (two for extreme death–US intervals of 165 and 166 h; one for open eyelids). Median gestational age was 29.3 weeks (IQR 27.2–32.9); median birthweight was 1325 g (IQR 980–1880). The cornea-to-eyeball volume ratio was an independent predictor of PMI (p < 0.001). The GBM model explained 91% of the variance in the training cohort (R2 = 0.91, RMSE = 11.49 h, MAE = 8.45 h) and 75% in the validation cohort (R2 = 0.75, RMSE = 18.32 h, MAE = 14.49 h), demonstrating strong predictive accuracy and minimal overfitting. Variable importance analysis confirmed the cornea-to-eyeball ratio as the most influential and biologically plausible predictor of PMI. A Shiny web application was developed to facilitate clinical implementation. Conclusions: 3D PM-US measurements of the fetal cornea and eyeball can reliably and quantitatively estimate the PMI with good predictive accuracy using a GBM model. Multicenter studies are required to further refine the model, enable external validation, and determine its clinical and forensic utility. Full article
(This article belongs to the Special Issue Novel Insights for Imaging and Therapy in Maternal and Fetal Medicine)
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