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Clinical Guidelines on the Management of Inflammatory Bowel Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (20 March 2025) | Viewed by 3160

Special Issue Editor


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Guest Editor
Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, 20132 Milan, Italy
Interests: inflammatory bowel disease; ulcerative colitis; irritable bowel syndrome; gastrointestinal diseases; IBS; endoscopy; gastrointestinal endoscopy; colonoscopy; Crohn’s disease; celiac disease; bowel ultrasound

Special Issue Information

Dear Colleagues,

Inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis, are chronic conditions that significantly impact the patients’ quality of life. When not adequately controlled, IBDs can lead to serious complications such as fistulas, abscesses, hospitalizations, and surgeries. Over the past few decades, the management of IBDs has evolved considerably due to advances in our understanding of the disease’s etiopathogenetic mechanisms, the increased availability of therapeutic options, and the use of tight monitoring strategies such as fecal calprotectin and intestinal ultrasound.

While newer therapies have transformed the treatment landscape, some patients still do not respond adequately, making their management challenging. In addition to discussing cutting-edge therapies, we will also address the use of older treatments such as azathioprine, exploring how to optimize its use in practice, particularly in specific patient populations where it may still offer benefits.

This Special Issue aims to summarize the latest evidence on the management of both Crohn’s disease and ulcerative colitis, offering practical recommendations for daily clinical practice.

Dr. Federica Furfaro
Guest Editor

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Keywords

  • inflammatory bowel diseases
  • Crohn’s disease
  • ulcerative colitis
  • post-operative
  • endoscopy
  • video capsule
  • bowel ultrasound
  • therapy
  • non-invasive markers

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Published Papers (2 papers)

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Research

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9 pages, 434 KiB  
Article
Impact of Psychosocial Factors on the Activity of Crohn’s Disease: A Cross-Sectional Analysis of Social Support, Stress, and Flare-Up Incidence
by María José de Dios-Duarte, Andrés Arias and Ana Barrón
J. Clin. Med. 2024, 13(11), 3086; https://doi.org/10.3390/jcm13113086 - 24 May 2024
Cited by 1 | Viewed by 2220
Abstract
Background/Objectives: Crohn’s disease is a chronic and debilitating intestinal disorder that alternates between remission and active flare-ups, often leading to hospitalization. Social support is known to enhance adaptation to the disease and modulate stress perception in patients, while stress may exacerbate symptoms. [...] Read more.
Background/Objectives: Crohn’s disease is a chronic and debilitating intestinal disorder that alternates between remission and active flare-ups, often leading to hospitalization. Social support is known to enhance adaptation to the disease and modulate stress perception in patients, while stress may exacerbate symptoms. The aim of this study was to examine the roles of perceived stress and social support in Crohn’s disease and their impact on the frequency of flare-ups. Methods: A cross-sectional observational study was conducted, assessing stress and social support in a cohort of 91 patients with Crohn’s disease during flare-up and remission phases. The Perceived Stress Scale (PSS-14) and a Social Support Questionnaire were utilized for evaluation. We examined the relationship between stress and social support in Crohn’s disease. The interaction between the variables studied was also observed, considering the stage of the disease. Finally, we carried out an analysis of the influence of these two variables on the development of flare-ups in Crohn’s disease. Results: The study revealed that patients experience higher stress levels during flare-ups and that these levels are amplified by a lack of social support. A significant relationship was identified between the levels of social support and the occurrence of flare-ups, indicating that better social support is associated with fewer flare-ups. Conclusions: Patients with Crohn’s disease in the flare-up phase are subject to considerable stress. A deficit in social support is linked to an increase in stress levels. The interaction between social support and stress plays a critical role in the development of flare-ups. Full article
(This article belongs to the Special Issue Clinical Guidelines on the Management of Inflammatory Bowel Diseases)
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Review

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13 pages, 1455 KiB  
Review
Long-Term Complications of Proctectomy for Refractory Perianal Crohn’s Disease: A Narrative Review
by Bruno Augusto Alves Martins, Mariana Trotta Villar, Luna Vitória Gondim Ferreira, Beatriz da Costa Rossi Ramos de Carvalho, Nicolas Avellaneda and João Batista de Sousa
J. Clin. Med. 2025, 14(8), 2802; https://doi.org/10.3390/jcm14082802 - 18 Apr 2025
Viewed by 451
Abstract
Despite a combination of medical and surgical treatments, many patients with perianal Crohn’s disease (CD) continue to experience refractory disease, requiring proctectomy or proctocolectomy, with the creation of a permanent stoma. Although proctectomy is seen as an ultimate treatment aimed at effectively relieving [...] Read more.
Despite a combination of medical and surgical treatments, many patients with perianal Crohn’s disease (CD) continue to experience refractory disease, requiring proctectomy or proctocolectomy, with the creation of a permanent stoma. Although proctectomy is seen as an ultimate treatment aimed at effectively relieving debilitating symptoms and enhancing quality of life, many patients may still face long-term and chronic complications. This narrative review aims to provide an overview of the main complications that patients undergoing proctectomy for CD may experience throughout their lives. Relevant publications addressing complications of proctectomy for refractory perianal CD were searched in the Medline/PubMed, Embase, Cochrane, and LILACS databases. The main long-term complications that patients encounter are related to impaired perineal wound healing, stoma-related issues, sexual and urinary dysfunction, small bowel obstructions, and CD recurrence. These complications negatively affect the quality of life and frequently necessitate further treatment. Patients should receive preoperative counselling regarding the implications of these particular issues, and regular follow-up must be guaranteed to identify any problems early, allowing for prompt treatment. Full article
(This article belongs to the Special Issue Clinical Guidelines on the Management of Inflammatory Bowel Diseases)
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