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JCDD
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Endothelial Regulation of Cardiac Development, Homeostasis, and Pathology
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Endothelial Regulation of Cardiac Development, Homeostasis, and Pathology

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Cardiac Development and Regeneration".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 4693

Special Issue Editors

Dr. Rubén Marín-Juez

E-Mail Website
Guest Editor
CHU Sainte Justine Research Center, Montreal, QC H3T 1C5, Canada
Interests: heart regeneration; Endothelium; angiogenesis; cardiovascular genetics; zebrafish
Dr. Gonzalo del Monte-Nieto

E-Mail Website
Guest Editor
Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia
Interests: heart development; endocardium; extracellular matrix; biomechanical forces; congenital heart disease; mouse

Special Issue Information

Dear Colleagues,

Endothelial cells are a major component of the developing and adult heart. Besides its classical role as a transport system, the cardiac endothelium (vascular and endocardial) has gained increasing attention in recent years as a key regulator of cardiac morphogenesis, pathogenesis, repair, and regeneration. For this Special Issue of the Journal of Cardiovascular Development and Disease (JCDD), we welcome contributions focused on the crosstalk between the cardiac endothelium and the different cardiac components including (but not limited to) the epicardium, fibroblasts, nerves, immune cells, cardiomyocytes, the valve mesenchyme, and the extracellular matrix.

Dr. Rubén Marín-Juez
Dr. Gonzalo del Monte-Nieto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endothelium
  • heart
  • coronaries
  • endocardium
  • development
  • regeneration
  • disease modeling

Published Papers (1 paper)

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Review

25 pages, 1563 KiB  
Review
Endocardial Regulation of Cardiac Development
by Lara Feulner, Patrick Piet van Vliet, Michel Puceat and Gregor Andelfinger
J. Cardiovasc. Dev. Dis. 2022, 9(5), 122; https://doi.org/10.3390/jcdd9050122 - 19 Apr 2022
Cited by 5 | Viewed by 3881
Abstract
The endocardium is a specialized form of endothelium that lines the inner side of the heart chambers and plays a crucial role in cardiac development. While comparatively less studied than other cardiac cell types, much progress has been made in understanding the regulation [...] Read more.
The endocardium is a specialized form of endothelium that lines the inner side of the heart chambers and plays a crucial role in cardiac development. While comparatively less studied than other cardiac cell types, much progress has been made in understanding the regulation of and by the endocardium over the past two decades. In this review, we will summarize what is currently known regarding endocardial origin and development, the relationship between endocardium and other cardiac cell types, and the various lineages that endocardial cells derive from and contribute to. These processes are driven by key molecular mechanisms such as Notch and BMP signaling. These pathways in particular have been well studied, but other signaling pathways and mechanical cues also play important roles. Finally, we will touch on the contribution of stem cell modeling in combination with single cell sequencing and its potential translational impact for congenital heart defects such as bicuspid aortic valves and hypoplastic left heart syndrome. The detailed understanding of cellular and molecular processes in the endocardium will be vital to further develop representative stem cell-derived models for disease modeling and regenerative medicine in the future. Full article
(This article belongs to the Special Issue Endothelial Regulation of Cardiac Development, Homeostasis, and Pathology)
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