Special Issue "Cardiac Regeneration in Non-Mammalian Vertebrates"
A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425).
Deadline for manuscript submissions: closed (31 October 2018).
Interests: organ regeneration; cardiomyocyte proliferation; cardiomyocyte dedifferentiation; immune cell function; conditional knockout analysis
JCDD is launching a Special Issue on "Cardiac Regeneration in Non-Mammalian Vertebrates", which focuses on recent advances in understanding the genetic, molecular, and cellular mechanisms underpinning robust regeneration of a damaged heart in non-mammalian vertebrates, such as zebrafish and salamanders. Research using non-mammalian vertebrates has inspired new priorities in cardiac regeneration science. For example, classical and recent studies using newts and axolotls provided evidence for cell cycle re-entry of differentiated cardiomyocytes after injury. More recently, genetic fate-mapping studies using zebrafish definitively identified cardiomyocytes (not stem cells) as the primary cellular source for muscle replacement during regeneration, significantly influencing the direction of the field in seeking future therapies focused on cardiomyocyte renewal to repair human hearts. Knowledge is still limited, but the field has been rapidly evolving in the last decade with new genetic approaches including conditional gene expression techniques and targeted mutagenesis, providing insights that may help to understand how cardiac regeneration naturally proceeds in the permissive animals and the cellular and molecular roadblocks to mammalian adult organ regeneration. This Special Issue will provide a platform to discuss current understanding of the endogenous mechanisms of cardiac regeneration in non-mammalian vertebrates which brings hope of providing new directions for future investigation into this burgeoning and exciting area of regeneration science.
Dr. Kazu Kikuchi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Heart regeneration
- Myocardial infarction
- Heart failure
- Cardiomyocyte proliferation
- Animal models