Multifaceted Roles of Extracellular Vesicles in Cancer and Other Diseases

Dear Colleagues,

Extracellular vesicles (EVs) comprise highly heterogeneous nano-sized particles, encompassing exosomes, microvesicles, and apoptotic bodies, which have come into the spotlight in current oncological research due to their implications in cancer and their emerging role as next-generation diagnostic and therapeutic modalities. These vesicles are released by a wide variety of cells within the tumor and its microenvironment, playing a significant role in cell-to-cell crosstalk via their diverse embedded cargoes. These cargoes can modify the functional state of recipient cells and ultimately promote disease development and progression. A deeper understanding of their biological role in cancer, as well as in several other diseases, including neurodegenerative, cardiovascular, infectious, and autoimmune disorders, along with recent advancements in EV isolation, characterization, and engineering methodologies, will open up new horizons for the development of liquid-biopsy-based diagnostics and therapeutic tools. We welcome state-of-the-art research and high-impact contributions regarding EV-mediated diagnostics and therapeutics in oncology and other disease contexts in this Special Issue entitled “Multifaceted Roles of Extracellular Vesicles in Cancer and Other Diseases.”

Dr. Eleni Myrto Trifylli
Guest Editor

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