Transcription in Cancer Initiation and Progression

Dear Colleagues,

The transformation of normal, healthy cells into cancer cells is a complex multistep process associated in most cases with the de-differentiation of specialized cells, re-entrance of G0/G1 arrested cells to mitotic divisions, ability to spread and invade tissues, as well as with immortality. Although the initiation of carcinogenesis is linked with mutations and loss of genomic stability, the following promotion and progression steps require alteration also in other “-omics”. Transcriptional reprogramming adapts the proteome of the transforming cell to new phenotypes by facilitating the gradual decrease in expression of cell type or highly specific tissue genes, and enhancing expression of factors that promote proliferation, migration, and metastases.

Our issue is dedicated to the elucidation of the essential transcription-relevant events that contribute to carcinogenesis, and to the identification of emerging hubs where gene transcription and malignancy interact with each other. Therefore, we invite submissions that cover genome-wide as well as gene-specific chromatin remodeling that accompanies all stages of tumor development. We aim to identify transcription factors, co-factors, nucleosome readers, writers, and erasers that drive cell transformation. Our Specials Issue also aims to publish papers dealing with the molecular basis of oncogene expression, repression of tumor suppressors, role of cell cycle progression, and E2F-dependent gene transcription in gaining the cancer phenotype. Likewise, we are particularly interested in all aspects dealing with transcription of factors, which make malignant cells resistant to anti-cancer approaches.

Dr. Agnieszka Zdzislawa Robaszkiewicz
Prof. Dr. Andre Tremblay
Guest Editors

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• Cancer
• Transcription
• Transcription factors and co-factors
• Chromatin remodeling
• Epigenetic modification
• Oncogenes
• Suppressors
• Cell cycle
• E2F-dependent gene transcription
• Tumor resistance
• Signaling