Special Issue "Proteolysis in Allergic Sensitization and Th2 Response"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 May 2017).
Interests: new diagnostic possibilities of allergies; innovative therapeutic approaches; allergens of birch and other selected trees; mugwort and ragweed pollen
Interests: structure and mechanism of proteins in immunology and blood coagulation; antigen processing and presentation; cellular defense mechanisms; bacterial collagenases; allergen molecules; prostatic and epidermal kallikreins
There is convincing evidence that protease activity is linked to the capacity of certain allergens to induce sensitization and Th2 responses. It has been shown that the combined effects of serine- and cysteine-protease activities on epithelial barrier and on innate and adaptive immunity favor Th2 and IgE responses. A role of the protease activity of allergens on the function of adaptive immune cells has been demonstrated for the major house dust mite allergen, Der p 1, which cleaves the low-affinity IgE receptor CD23 on B-cells, thereby disrupting the negative feedback loop for IgE production. Der p 1 also cleaves CD25, the α-subunit of the T-cell IL-2 receptor, leading to inhibition of T-cell proliferation and production of IFN-γ, thus favoring Th2 responses. Several other pro-allergenic effects of Der p 1 on dendritic cells have been described, including decreased IL-12 production, inhibition of indoleamine-2,3-dioxygenase production, and cleavage of CD40 and DC-SIGN molecules.
Proteases in allergen sources have also been suggested to contribute to primary sensitization to allergens and to exacerbation of allergic disorders. Such non-allergen proteases were shown to compromise epithelial barrier function, to activate innate immune responses, and to facilitate allergen accessibility to dendritic cells. In addition, proteases have been shown to induce epithelial cells to produce thymic stromal lymphopoietin (TSLP), which triggers dendritic cells maturation.
This Special Issue, “Proteolysis in allergic sensitization and Th2 response”, aims to provide a summary of the field, to explore recent advances in protease-immune system interactions, and to discuss how proteolytic events may drive Th2 polarization and allergic sensitization/inflammation. We invite authors to submit original research and review articles related to any of these aspects.
Prof. Dr. Fatima Ferreira
Prof. Dr. Hans Brandstetter
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- Protease allergens
- Proteolytic processing of allergens
- Type 1 allergy
- T helper 2 cell
- Protease-activated receptors (PAR)
- Allergen source-derived proteases
- Innate immune cells
- Allergic sensitization
- Allergic inflammation
- Epithelial barrier