Protein Structural Dynamics 2019

Dear colleagues,

Protein structural dynamics is intimately related to protein functions. Structure biology demands high-resolution structures primarily coming from X-ray crystallography. However, the crystal structure does not always give a comprehensive understanding of the functional mechanism. This inability is often ascribed to a lack of insight into the time-dependent spatial rearrangement of the regulatory residues, domains, and subunits in proteins, which emphasizes the importance in exploring how structural dynamics engages in functional regulation in proteins. Progress in the experimental and theoretical approaches has improved our understanding of protein structural dynamics and has updated the protein structure and function relationships by adding the roles of structural dynamics. The technical advances have also expanded the research targets from folded proteins to intrinsically disordered proteins that travel much wider conformational spaces over the folded proteins. Intrinsically disordered proteins with liquid–liquid phase separation properties have become focused, which unveils the other remarkable roles of structural dynamics in regulating the phase transition of the protein solution.

The Special Issue “Protein Structural Dynamics 2019” is a continuation of the successful 2018 issue “Protein Structural Dynamics”. This issue also aims to present the contemporary research on protein structural dynamics, which may include original articles covering technical development, experimental reports on some particular proteins, and theoretical research, as well as review papers relating to the subjects.

Prof. Dr. Shin-ichi Tate
Guest Editor

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