Dear Colleagues, 

The main causes of mortality and morbidity are acute coronary syndrome and stroke, whichresult in immense health and economic burden. The current strategies to prevent acute coronary syndrome and ischemic stroke in at-risk patients depend on antiplatelet drugs (e.g., aspirin, P2Y12 inhibitors), which do not translate into clinical efficacy in one-third of patients. Other potent antiplatelet agents such as glycoprotein IIb/IIIa inhibitors (e.g., abciximab) are associated with bleeding complications and are not suitable for long-term use. Therefore, understanding the cellular mechanism that regulates platelet activation and thrombosis is of considerable importance. Recently, metabolic pathways are increasingly being recognized as potential targets for therapeutic interventions. Although bioenergetic profile studies performed in platelets suggest the existence of metabolic plasticity, very little is known about the mechanistic role of cellular metabolism in platelet function. A recent report showed that platelet metabolic (glycolytic) enzyme can modulate platelet function and thrombosis without altering hemostasis. Thus, targeting different enzymes of metabolic pathways and metabolites of platelets and different cells (neutrophil, monocytes, and endothelial cells) that take part in development of thrombosis could be a potential future goal for antithrombotic therapeutic intervention.

This Special Issue is devoted to discussing new insights into thrombosis, influenced by platelet metabolism or different platelet metabolic enzymes or metabolites. This issue also includes mechanistic insights about platelet lifespan/aging and its metabolism, platelet metabolism during storage, and the effect of temperature on platelet metabolism.

Dr. Manasa K. Nayak
Dr. Dong Ju Son
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• thrombosis
• platelet metabolism
• metabolic enzymes
• anti-platelet drugs
• anti-thrombotic drugs
• metabolic plasticity
• hemostasis
• cardiovascular disease
• platelet lifespan/aging
• platelet metabolism during storage