Bioactive Oxadiazoles 2.0

Dear Colleagues,

This Special Issue is the continuation of our previous Special Issue “Bioactive Oxadiazoles”.

Oxadiazoles are electron-poor five-membered aromatic heterocycles containing one oxygen and two nitrogen atoms. The oxadiazoles, namely 1,2,3-, 1,2,4-, 1,2,5-, and 1,3,4-regioisomers, together with N-oxides, benzo-fused, and non-aromatic derivatives, present a wide application range from material science to explosives and bioactive compounds. In the latter field, there are many possibilities and oxadiazoles revealed to be active as antitumoral agents, neuroprotective compounds, antimicrobials, antivirals, antidiabetics, and so on. Some bioactive oxadiazoles have reached the market or are in the advanced clinical trials stage, such as oxolamine, ataluren, raltegravir, capeserod, azilsartan, furazabol, sydnophen, zibotentan, opicabone, etc. Moreover, the oxadiazole skeleton is also present in some natural compounds, such as phidianidine and quisqualic acid, giving new inspiration to the synthesis of bio-inspired drugs. Another important issue is the use of oxadiazoles in medicinal chemistry as amide and ester isosters and as peptido-mimetics, offering a well-established tool for drug design. All these aspects have increased interest in these heterocycles, increasing the impact of oxadiazoles in the field of bioactive compounds. This Special Issue on “Bioactive Oxadiazoles” is intended to offer a wide panorama of the potential applications of these compounds toward all diseases.

The research fields of this Special Issue include natural products, synthetic chemistry, medicinal chemistry, pharmacology, and other related research fields. Original research and review articles on all topics in these research fields are invited. I look forward to receiving many submissions from outstanding experts on these research topics.

Prof. Dr. Antonio Palumbo Piccionello
Guest Editor

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