Role of Neuronal Guidance Cues in Inflammation and Vascular Biology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 32372
Special Issue Editor
Interests: axonal guidance cues; endothelium; monocyte; macrophage; atherosclerosis; netrin; cell biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The observation that the anatomy and genetic expression patterns of the vascular system of vertebrates often overlap with the nervous system has led to one of the major recent insights in developmental vascular biology, i.e., that the coordinated patterning of nerves and vessels is achieved by each system separately using the same cues and signals. These conserved patterning factors, together known as neuronal guidance cues, were first identified in neural development and involve four major families of conserved ligands netrins, slits, semaphorins, and ephrins. More recently, their critical roles in physiological and pathological regulation of vascular biology and immune responses have been increasingly recognized. As has been shown by their roles in various vascular (patho)physiologies, such as atherosclerosis development and progression, endothelial (blood-brain) barrier, retinopathy, and tumor angiogenesis.
The scope of this Special Issue covers the various roles of neuronal guidance cues in inflammation and vascular biology. We welcome contributions of original research articles, as well as review articles, that further unravel the role of neuronal guidance molecules in inflammation and vascular biology. We encourage the submission of papers approaching the topic from different points of view and different levels, from both micro- and microvasculature as well as lymphatic vasculature, and from basic molecular mechanisms and to translational approaches. Different approaches can extend our knowledge of neuronal guidance molecules can contribute to future therapeutic strategies aim to preserve and improve vascular health.
Dr. Janine van Gils
Guest Editor
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