Next Article in Journal
Nanogels of a Succinylated Glycol Chitosan-Succinyl Prednisolone Conjugate: Release Behavior, Gastrointestinal Distribution, and Systemic Absorption
Next Article in Special Issue
The Current Understanding of Autophagy in Nanomaterial Toxicity and Its Implementation in Safety Assessment-Related Alternative Testing Strategies
Previous Article in Journal
Proteomic Analysis of Renal Biomarkers of Kidney Allograft Fibrosis—A Study in Renal Transplant Patients
Previous Article in Special Issue
Cytotoxicity of NiO and Ni(OH)2 Nanoparticles Is Mediated by Oxidative Stress-Induced Cell Death and Suppression of Cell Proliferation
Review

Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure

1
Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666 Al Ain, UAE
2
Zayed Center for Health Sciences, United Arab Emirates University, P.O. Box 17666 Al Ain, UAE
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2375; https://doi.org/10.3390/ijms21072375
Received: 14 October 2019 / Revised: 14 December 2019 / Accepted: 18 December 2019 / Published: 30 March 2020
(This article belongs to the Special Issue Nanotoxicology and Nanosafety 2.0)
Engineered nanomaterials (ENMs) have gained huge importance in technological advancements over the past few years. Among the various ENMs, silver nanoparticles (AgNPs) have become one of the most explored nanotechnology-derived nanostructures and have been intensively investigated for their unique physicochemical properties. The widespread commercial and biomedical application of nanosilver include its use as a catalyst and an optical receptor in cosmetics, electronics and textile engineering, as a bactericidal agent, and in wound dressings, surgical instruments, and disinfectants. This, in turn, has increased the potential for interactions of AgNPs with terrestrial and aquatic environments, as well as potential exposure and toxicity to human health. In the present review, after giving an overview of ENMs, we discuss the current advances on the physiochemical properties of AgNPs with specific emphasis on biodistribution and both in vitro and in vivo toxicity following various routes of exposure. Most in vitro studies have demonstrated the size-, dose- and coating-dependent cellular uptake of AgNPs. Following NPs exposure, in vivo biodistribution studies have reported Ag accumulation and toxicity to local as well as distant organs. Though there has been an increase in the number of studies in this area, more investigations are required to understand the mechanisms of toxicity following various modes of exposure to AgNPs. View Full-Text
Keywords: silver nanoparticles; cytotoxicity; routes of exposure; biodistribution silver nanoparticles; cytotoxicity; routes of exposure; biodistribution
Show Figures

Figure 1

MDPI and ACS Style

Ferdous, Z.; Nemmar, A. Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure. Int. J. Mol. Sci. 2020, 21, 2375. https://doi.org/10.3390/ijms21072375

AMA Style

Ferdous Z, Nemmar A. Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure. International Journal of Molecular Sciences. 2020; 21(7):2375. https://doi.org/10.3390/ijms21072375

Chicago/Turabian Style

Ferdous, Zannatul, and Abderrahim Nemmar. 2020. "Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure" International Journal of Molecular Sciences 21, no. 7: 2375. https://doi.org/10.3390/ijms21072375

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop